Therapeutic Angiogenesis for Vascular Diseases

1. Front Matter

   Pages i-xvi

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2. Modified 3D-Fibrin Matrices in Tissue Engineering for Stimulation of Angiogenesis and Wound Healing

   • Heike Hall

   Pages 1-26

3. Ocular Retinopathies and Clinical Control of Angiogenesis

   • Bin Zhang, Jian-xing Ma

   Pages 27-65

4. Angiogenic Gene Therapy for the Treatment of Retinopathies

   • Jacob M. Jones, Trevor McFarland, J. Timothy Stout

   Pages 67-80

5. Angiogenesis in Tumour Development and Metastasis

   • Jessica J. Kandel, Darrell J. Yamashiro, Jan Kitajewski

   Pages 81-93

6. Cancer Therapy by Targeting Vascular Endothelial Cell Growth Factor- and Non-Vascular Endothelial Cell Growth Factor-Mediated Angiogenesis

   • Yihai Cao

   Pages 95-113

7. Molecular Mechanisms of Post-Ischemic Angiogenesis in the Brain

   • Heike Beck

   Pages 115-143

8. Angiogenesis, the Neurovascular Niche and Neuronal Reintegration After Injury

   • Erin Lavik, Joseph A. Madri

   Pages 145-167

9. Safe and Effective Vascular Endothelial Cell Growth Factor (VEGF)-based Therapeutic Angiogenesis for Ischemic Stroke: Insights from Preclinical Trials

   • Panya S. Manoonkitiwongsa, Robert L. Schultz, Patrick D. Lyden

   Pages 169-212

10. Atherosclerotic Plaque Angiogenesis as a Mechanism of Intraplaque Hemorrhage and Acute Coronary Rupture

    • Frank D. Kolodgie, Aloke V. Finn, Jagat Narula, Renu Virmani

    Pages 213-236

11. Neovascularization and Intra-plaque Hemorrhage: Role of Haptoglobin, Macrophages, and Heme-Oxygenase-1 Pathway

    • K-Raman Purushothaman, Meerarani Purushothaman, Andrew P. Levy, Samin K. Sharma, Valentin Fuster, Pedro R. Moreno

    Pages 237-256

12. Angiogenic Approaches for Inhibition of Plaque Destabilization in Atherosclerosis

    • Konstantinos Toutouzas, Andreas Synetos, Christodoulos Stefanadis

    Pages 257-265

13. A Key Role of Angiogenic Control in Recovery from Ischaemic Heart Disease

    • John F. O’Sullivan, Anne-Laure Leblond, Noel M. Caplice

    Pages 267-294

14. Angiogenic Mediators and the Pathogenesis of Alzheimer’s Disease

    • Paula Grammas

    Pages 295-312

15. Vascular Development, Stroke and Neurodegenerative Disease: A Place for Novel Clinical Interventions?

    • Adrià Arboix, Marta Grau-Olivares, Jerzy Krupinski

    Pages 313-338

16. Peripheral Artery Disease and Angiogenesis: A Link Between Angiogenesis and Atherothrombosis

    • Philip C. Bennett, Stanley Silverman, Paramjit Gill, Gregory Y.H. Lip

    Pages 339-359

17. Role of Angiogenesis in the Pathogenesis of Arthritis: Potential Therapeutic Applications

    • Serafim Kiriakidis, Ewa M. Paleolog

    Pages 361-382

18. Angiogenesis and Giant Cell Arteritis

    • Sarah L. Mackie, Ann W. Morgan, Pamela F. Jones

    Pages 383-402

19. Moyamoya Disease

    • Ahmed Itrat, Ayeesha Kamal

    Pages 403-416

20. “Overview on Nanotechnology and Angiogenesis in Major Diseases Processes”

    • Judith Sendra Cuadal, Mercè Morral, Marc Ramis-Castelltort

    Pages 417-424

Angiogenesis is the growth of new blood vessels and is a key process which occurs during pathological disease progression. Excessive and damaging angiogenesis occurs in diseases such as cancer, diabetic retinopathies, age-related macular degeneration and atherosclerosis. In other diseases such as stroke and myocardial infarction, insufficient or improper angiogenesis results in tissue loss and ultimately higher morbidity and mortality. In this book we will begin by providing the reader with an overview of the process of angiogenesis including normal embryological development of blood vessels. The following chapters will each focus on a key angiogenic disease incorporating current scientific knowledge concerning the causes of activation of the “angiogenic switch”, pathological consequences, current treatment options and future perspectives. Where appropriate, results from pre-clinical trials, novel imaging modalities and nanotechnological approaches will be incorporated into these sections. Finally, since it is now believed that the process of angiogenesis operated via different signalling mechanisms in different vascular beds, we will discuss our current understanding of this phenomenon. The target audience for this book would include researchers in all the basic sciences; post-graduate students at Universities and Institutes; pharmaceutical industries; clinicians working in vascular biology or tissue imaging; pathologists; neurologists; tumour biologists; ophthalmologists and cardiologists.

• Angiogenesis
• Imaging
• Therapy

• , SBCHS, John Dalton Building, Manchester Metropolitan University, Manchester, United Kingdom

  Mark Slevin

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