Endotoxins: Structure, Function and Recognition

1. Front Matter

   Pages i-xvii

   PDF

2. Part I Structure and Properties of Endotoxins

   1. Front Matter

      Pages 1-1

      PDF

   2. Endotoxins: Lipopolysaccharides of Gram-Negative Bacteria

      • Xiaoyuan Wang, Peter J. Quinn

      Pages 3-25

   3. Purification and Characterization of Lipopolysaccharides

      • Xiaoyuan Wang, Chan Zhang, Feng Shi, Xiaoqing Hu

      Pages 27-51

   4. Endotoxins: Relationship Between Structure, Function, and Activity

      • K. Brandenburg, A.B. Schromm, T. Gutsmann

      Pages 53-67

   5. The Diversity of the Core Oligosaccharide in Lipopolysaccharides

      • Alba Silipo, Antonio Molinaro

      Pages 69-99

   6. Salmonella-Regulated Lipopolysaccharide Modifications

      • Susan M. Richards, Kristi L. Strandberg, John S. Gunn

      Pages 101-122

   7. The Variation of O Antigens in Gram-Negative Bacteria

      • Lei Wang, Quan Wang, Peter R. Reeves

      Pages 123-152

   8. Regulators of TLR4 Signaling by Endotoxins

      • Anne F. McGettrick, Luke A.J. O’Neill

      Pages 153-171

   9. Membrane Partitioning: Is Location Everything When It Comes to Endotoxin Recognition?

      • Martha Triantafilou, Kathy Triantafilou

      Pages 173-184

3. Infection, Treatment and Immunity

   1. Front Matter

      Pages 185-185

      PDF

   2. Endotoxin Detection – from Limulus Amebocyte Lysate to Recombinant Factor C

      • Jeak Ling Ding, Bow Ho

      Pages 187-208

   3. The Role of Endotoxin in Infection: Helicobacter pylori and Campylobacter jejuni

      • Anthony P. Moran

      Pages 209-240

   4. The Role of Pseudomonas Lipopolysaccharide in Cystic Fibrosis Airway Infection

      • Samuel M. Moskowitz, Robert K. Ernst

      Pages 241-253

   5. Development of Small-Molecule Endotoxin Sequestering Agents

      • Sunil A. David, Diptesh Sil

      Pages 255-283

   6. Development of an Anti-Endotoxin Vaccine for Sepsis

      • Alan S. Cross

      Pages 285-302

   7. Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvants

      • Christopher B. Fox, Martin Friede, Steven G. Reed, Gregory C. Ireton

      Pages 303-321

   8. Targeting Endotoxin in the Treatment of Sepsis

      • Jean-Sebastien Rachoin, Christa A. Schorr, R. Phillip Dellinger

      Pages 323-338

   9. Lipopolysaccharides in Rhizobium-Legume Symbioses

      • Russell W. Carlson, L. Scott Forsberg, Elmar L. Kannenberg

      Pages 339-386

   10. Lipopolysaccharides and Plant Innate Immunity

       • G. Erbs, A. Molinaro, J.M. Dow, M.-A. Newman

       Pages 387-403

Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

• Antigen
• Sepsis
• bacteria
• infection
• infectious
• vaccine
• infectious diseases

From the reviews:

“The book consists of two parts that include 17 chapters prepared by an international team of well_ known experts. … The book is well prepared. There are many good quality photos, graphs, and pictures. Each chapter ends with a base reference, and there is a subject index at the end of the book. … very useful for many researchers in the field of biochemistry, biotechnology, immunology, and medicinal chemistry. This book can also be a useful tool for teachers and students of colleges and universities.” (G. Ya. Wiederschain, Biochemistry, Vol. 76 (5), May, 2011)

• Dept. Biochemistry, Jiangnan University, Wuxi, Jiangsu, China, People's Republic

  Xiaoyuan Wang

• European Southern Observatory (ESO), Garching, Germany

  Peter J. Quinn

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