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Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy

  • Book
  • © 2010

Overview

Editors:
  1. Nándor Ács

    1. , Second Department of Obstetrics and Gyne, Semmelweis University, Budapest, Hungary

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  2. Ferenc G. Bánhidy

    1. Second Department of Obstetrics and Gyne, Semmelweis University, Budapest, Hungary

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    You can also search for this editor in PubMed   Google Scholar

  3. Andrew E. Czeizel

    1. Hereditary Diseases, Foundation f. Community Control of, Budapest, Hungary

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  • uniquely large database
  • systematic analysis of maternal diseases
  • recommendations for future studies

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xxii
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  2. The Study Population and Methods

    1. Front Matter

      Pages 1-1
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    2. The Hungarian Congenital Abnormality Registry (HCAR)

      • Nándor Ács, Ferenc G. Bánhidy, Andrew E. Czeizel
      Pages 3-61

  3. Results of Studies and Their Interpretation

    1. Front Matter

      Pages 63-63
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    2. Certain Infectious and Parasitic Diseases

      • Nándor Ács, Ferenc G. Bánhidy, Andrew E. Czeizel
      Pages 65-110

    3. Neoplasms

      • Nándor Ács, Ferenc G. Bánhidy, Andrew E. Czeizel
      Pages 111-116

    4. Diseases of the Blood and Blood-Forming Organs

      • Nándor Ács, Ferenc G. Bánhidy, Andrew E. Czeizel
      Pages 117-123

    5. Endocrine, Nutritional and Metabolic Diseases

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 125-147

    6. Mental and Behavioural Disorders

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 149-162

    7. Diseases of the Nervous System

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 163-191

    8. Diseases of the Eye and Adnexa

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 193-193

    9. Diseases of the Ear and the Mastoid Process

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 195-199

    10. Diseases of the Circulatory System

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 201-249

    11. Diseases of the Respiratory System

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 251-278

    12. Diseases of the Digestive System

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 279-328

    13. Diseases of the Skin and Subcutaneous Tissue

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 329-333

    14. Diseases of the Musculoskeletal System and Connective Tissue

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 335-340

    15. Diseases of the Urinary Tract

      • Nándor Ács, Ferenc G. Bánhidy, Andrew E. Czeizel
      Pages 341-363

    16. Diseases of the Genital Organs

      • Nándor Ács, Ferenc G. Bánhidy, Andrew E. Czeizel
      Pages 365-413

    17. Pregnancy, Childbirth, and the Pueperium

      • Nándor Ács, Ferenc Bánhidy, Andrew E. Czeizel
      Pages 415-424
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Keywords

About this book

The major objective of our studies in the last decade was a systematic analysis of maternal diseases during pregnancy to reveal their possible adverse effects on birth outcomes. The two most important factors of infant mortality were parti- larly analyzed: structural birth defects, known as congenital abnormalities (CAs) and preterm birth (PB). In general the objectives of scienti c studies might be either to test a new hypothesis or to con rm or confront previously published results. However, less frequently the authors/scientists have personal motivations determined by their professional activities. The authors of this book are practicing physicians and genetic epidemiologist who are mainly interested in the following three practical questions: 1. The possible adverse effects of pharmaceutical products. The possible t- atogenic potential of about 170 drugs has been evaluated very thoroughly using the data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) in the last 50 years. These drugs were used to treat maternal diseases and the ndings of our population-based case-control studies will be cited in this book and are shown in the Appendix at the end of the book. However, our long experiences showed two problems in the drug teratology. In general the evaluation of clinical doses of these drugs is a particularly dif- cult challenge due to the modi cation effects of confounders. This problem motivated one of the authors to establish a new model of disaster epidemiology.

Reviews

From the reviews:

“In this presentation of the Hungarian Congenital Abnormality Registry, the authors use a large case-control analysis to determine the risk of pregnancy malformations in a variety of maternal conditions. … The audience includes obstetricians or practitioners involved in high-risk obstetrics. … This is an ambitious presentation of one country’s risk of congenital abnormalities and preterm birth.” (Anthony Shanks, Doody’s Review Service, October, 2010)

Editors and Affiliations

  • , Second Department of Obstetrics and Gyne, Semmelweis University, Budapest, Hungary

    Nándor Ács

  • Second Department of Obstetrics and Gyne, Semmelweis University, Budapest, Hungary

    Ferenc G. Bánhidy

  • Hereditary Diseases, Foundation f. Community Control of, Budapest, Hungary

    Andrew E. Czeizel

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