Signal Transducers and Activators of Transcription (STATs)

1. Front Matter

   Pages i-xxiv

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2. Introduction: A Brief History of the STATs and a Glance at the Future

   1. Introduction: A Brief History of the STATs and a Glance at the Future

      • James E. Darnell Jr.

      Pages 1-8

3. STAT Proteins and Their Regulators

   1. Front Matter

      Pages 9-9

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   2. The STAT Protein Family

      • Markus H. Heim

      Pages 11-26

   3. The Janus Kinase Protein Family

      • Pipsa Saharinen, Olli Silvennoinen

      Pages 27-42

   4. Structural Bases of Receptor-JAK-STAT Interactions

      • Peter C. Heinrich, Iris Behrmann, Serge Haan, Heike M. Hermanns, Gerhard Müller-Newen, Fred Schaper

      Pages 43-53

   5. SOCS Proteins

      • Robyn Starr, Douglas J. Hilton

      Pages 55-73

   6. The PIAS Protein Family and TC-PTP

      • Bin Liu, Ke Shuai

      Pages 75-85

   7. Prime Time for the Drosophila JAK/STAT Pathway

      • Erika A. Bach, Norbert Perrimon

      Pages 87-104

   8. The STAT Proteins of Dictyostelium

      • Jeffrey G. Williams

      Pages 105-121

   9. JAK/STATS in Zebrafish

      • Andrew C. Oates, Leonard I. Zon

      Pages 123-134

4. Mechanisms of Activation of and Transcriptional Regulation by STAT Proteins

   1. Front Matter

      Pages 135-135

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   2. IFNS and STATs, an Incestuous Relationship

      • Christian Schindler, Li Song

      Pages 137-154

   3. Mechanisms and Biological Roles of STAT Activation by the IL-6 Family of Cytokines

      • Daisuke Kamimura, Toshio Hirano

      Pages 155-175

   4. Growth Hormone Induced Activation and Regulation of JAK2 and STAT Proteins

      • Jason H. Kurzer, Christin Carter-Su

      Pages 177-190

   5. G Protein-Coupled-Receptor Mediated STAT Activation

      • José Miguel Rodríguez-Frade, Mario Mellado, Carlos Martínez-A.

      Pages 191-206

   6. Regulation of STATs by Posttranslational Modifications

      • Thomas Decker, Mathias Müller, Pavel Kovarik

      Pages 207-222

   7. Interactions of STATs with Src Family Kinases

      • Corinne M. Silva, Julie L. Boerner, Sarah J. Parsons

      Pages 223-236

   8. The Role of Phosphatases and Reactive Oxygen Species in Regulation of the JAK/STAT Pathway

      • Andrew Larner, Michael David

      Pages 237-245

   9. Raft-STAT Signaling and Transcytoplasmic Trafficking

      • Pravin B. Sehgal, Mehul Shah

      Pages 247-267

The year 2003 marks the tenth anniversary of the first use of the acronym "Stat" (also written "STAT") in the scientific literature for a family of transcription factors which rapidly transduce cytokine-and growth factor­ elicited signals from the plasma membrane to the cell nucleus thereby activating gene transcription (thus, . s. ignal Transducers and Activators of Transcription). From those beginnings, the field of STAT transcription factors, their related regulatory molecules and their biology has grown exponentially in many different directions. In recognition of the rapid growth and broad scope of the STAT transcription factor field today, and to celebrate the tenth anniversary of the use of this term in the scientific literature, Kluwer Academic Publishers B. V. requested us to compile a volume on STAT transcription factors that could serve as an overview of this burgeoning area. Thus, we wanted a volume that would serve as a reference for what is known about STAT proteins and their biology, would describe the current state of ongoing research in this broad area, and would look toward the future to try to predict the discoveries that lie ahead. Our charge was to seek out the very best experts in the field and to coax them to briefly summarize their areas of expertise.

• Activation
• Translation
• Viruses
• Vivo
• biological functions
• conservation
• gene expression
• gene transcription
• genetics
• proteins
• regulation
• transcription

• New York University School of Medicine, USA

  Pravin B. Sehgal, David E. Levy

• Osaka University, Japan

  Toshio Hirano

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