Editors:
- Unique book volume on the 2008 CCN SOciety Conference
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Table of contents (19 chapters)
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Front Matter
About this book
The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors.
The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types.
The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information.
The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology.
All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions.
In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes.
Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field.
Editors and Affiliations
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Ann Arbor, USA
Annick Perbal
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Okayama, Japan
Masaharu Takigawa
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Palais du Grand Large, International CCN Society, Saint-Malo, France
Bernard Perbal
Bibliographic Information
Book Title: CCN proteins in health and disease
Book Subtitle: An overview of the Fifth International Workshop on the CCN family of genes
Editors: Annick Perbal, Masaharu Takigawa, Bernard Perbal
DOI: https://doi.org/10.1007/978-90-481-3779-4
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2010
Hardcover ISBN: 978-90-481-3778-7Published: 06 May 2010
Softcover ISBN: 978-94-017-8291-3Published: 30 November 2014
eBook ISBN: 978-90-481-3779-4Published: 26 April 2010
Edition Number: 1
Number of Pages: XIII, 338
Topics: Biomedicine general, Gene Function, Molecular Medicine, Protein Science, Cell Biology