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Nuclear Receptors

Current Concepts and Future Challenges

  • Book
  • © 2010

Overview

  • Focuses on biology of nuclear receptors
  • Up to date reviews of diverse aspects of Nuclear Receptor biology
  • Contributions from authors of major standing in the Nuclear Receptor Field
  • Provides an outstanding reference book for new and established Nuclear Receptor researchers
  • First comprehensive book of its type since for almost 20 year

Part of the book series: Proteins and Cell Regulation (PROR, volume 8)

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Table of contents (18 chapters)

Keywords

About this book

In 1890 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the immediate improvement in the patient’s condition. A few years later, medications for the then ill-explained condition of the menopause included tablets made from cow ovaries. In the first quarter of the 20th century the identification of vitamin D, and its sunlight driven production in skin, paved the way to the elimination of rickets as a major medical problem. Twenty years or so later, Sir Vincent Wigglesworth established the endocrine basis of developmental moulting in insects, arguably the most commonly performed animal behaviour on Planet Earth. A paradigm that would unify these disparate observations arose between 1985 and 1987 beginning with the identification of the glucocorticoid receptor and the nuclear receptor super-family. What follows is a timely and positive manifestation of the capacity, productivity and value of international human scientific endeavour. Based on intrigue, lively competition and cooperation a global effort has rapidly fostered a school of biology with widespread ramifications for the understanding of metazoan animals, the human condition and the state of the planet. This book is the first this century to try and capture the spirit of this endeavour, to depict where the field is now and to identify some of the challenges and opportunities for the future.

Editors and Affiliations

  • School of Biosciences, University of Birmingham, Birmingham, United Kingdom

    Chris M. Bunce

  • Dept. Pharmacology & Therapeutics, Roswell Park Cancer Institute, Buffalo, U.S.A.

    Moray J. Campbell

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