Rabbit Biotechnology

1. Front Matter

   Pages i-viii

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2. Introduction

   • Louis-Marie Houdebine, Jianglin Fan

   Pages 1-2

3. Improvement of Rabbit Production

   • Shuji Kitajima

   Pages 3-12

4. Basic Methods for Experimental Rabbits

   • Kazutoshi Nishijima

   Pages 13-22

5. Useful Information for Rabbit Genes, Proteins, and Antibodies

   • Tomonari Koike, Jifeng Zhang, Jianglin Fan

   Pages 23-26

6. General Physiology of Rabbits

   • Masashi Morimoto

   Pages 27-35

7. Rabbit Transgenesis

   • Shuji Kitajima, Enqi Liu, Jianglin Fan

   Pages 37-47

8. Rabbit as a Model for the Study of Human Diseases

   • Masashi Shiomi

   Pages 49-63

9. Transgenic Rabbits to Prepare Pharmaceutical Proteins

   • Louis-Marie Houdebine, Geneviève Jolivet, Pierre-Jean Ripoll

   Pages 65-75

10. Derivation and Characterization of Rabbit Embryonic Stem Cells: A Review

    • Elen Gócza, Zsuzsanna Bősze

    Pages 77-104

11. Rabbit Cloning

    • Andras Dinnyes, Zsuzsanna Polgar, Qinggang Meng

    Pages 105-128

12. The European Rabbit Genome

    • Jessica Alföldi, Federica Di Palma, Kerstin Lindblad-Toh

    Pages 129-129

13. Back Matter

    Pages 131-132

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Louis-Marie Houdebine and Jianglin Fan The study of biological functions of proteins and their possible roles in the pathogenesis of human diseases requires more and more relevant animal m- els. Although mice including genetically modified mice offer many possibilities, other non-murine species are absolutely required in some circumstances. Rabbit is one of these species, which has been widely used in biomedical studies. This animal is genetically and physiologically closer to humans including cardiov- cular system and metabolism characteristics. Rabbit is thus more appropriate than mice to study some diseases such as atherosclerosis and lipid metabolism. Because of its larger size, surgery manipulation, bleeding, and turn-over studies are much easier performed in rabbits than in mice. Furthermore, transgenic rabbits can be produced using microinjection and other methods such as lentiviral v- tors. Cloning in rabbits has been proved possible, even though still laborious and time-consuming. Hopefully, functional rabbit ES cell lines will be available in the coming years. Gene deletion or knock-out in rabbits will then become possible.

• biological functions
• biotechnology
• cell lines
• cloning
• genes
• genome
• metabolism
• genetic engineering

• Institute of Research in Agronomy, Jouy en Josas, France

  Louis-Marie Houdebine

• Department of Molecular Pathology, Interdisciplinary Graduate, School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

  Jianglin Fan

Policies and ethics