Perspectives in Cancer Prevention-Translational Cancer Research

1. Front Matter

   Pages i-xii

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2. Nutrition in Cancer: Evidence-Based Nutrition Recommendations in Cancer Patients and Survivors

   • Anis Rashid

   Pages 1-7

3. Tumour Stem Cell Enrichment by Anticancer Drugs: A Potential Mechanism of Tumour Recurrence

   • T. R. Santhosh Kumar, M. Radhakrishna Pillai

   Pages 9-19

4. Curcumin: A Potent Candidate to be Evaluated as a Chemosensitizer in Paclitaxel Chemotherapy Against Cervical Cancer

   • Chanickal N. Sreekanth, Smitha V. Bava, Arun Kumar T. Thulasidasan, Nikhil P. Anto, Vino T. Cheriyan, Vineshkumar T. Puliyappadamba et al.

   Pages 21-43

5. Azadirachta indica (Neem) and Neem Limonoids as Anticancer Agents: Molecular Mechanisms and Targets

   • Siddavaram Nagini, Ramamurthi Vidya Priyadarsini

   Pages 45-60

6. In Vitro Studies on the Antioxidant/Antigenotoxic Potential of Aqueous Fraction from Anthocephalus cadamba Bark

   • Madhu Chandel, Upendra Sharma, Neeraj Kumar, Bikram Singh, Satwinderjeet Kaur

   Pages 61-72

7. Possible Involvement of Signal Transducer and Activator of Transcription-3 (STAT3) Signaling Pathway in the Initiation and Progression of Hepatocellular Carcinoma

   • Aruljothi Subramaniam, Muthu K. Shanmugam, Ekambaram Perumal, Feng Li, Alamelu Nachiyappan, Alan P. Kumar et al.

   Pages 73-87

8. Simple Sequence Repeats in 5′ and 3′ Flanking Sequences of Cell Cycle Genes

   • Seema Trivedi

   Pages 89-101

9. Mechanisms of Chemopreventive Activity of Sulforaphane

   • Yogesh C. Awasthi, Shailesh Jaiswal, Mukesh Sahu, Abha Sharma, Rajendra Sharma

   Pages 103-112

10. Reciprocal Relationship Between VE-Cadherin and Matrix Metalloproteinases Expression in Endothelial Cells and Its Implications to Angiogenesis

    • A. P. Athira, M. S. Kiran, P. R. Sudhakaran

    Pages 113-120

11. Androgen Receptor Expression in Human Thyroid Cancer Tissues: A Potential Mechanism Underlying the Gender Bias in the Incidence of Thyroid Cancers

    • Jone A. Stanley, Jone A. Stanley, Ramalingam Neelamohan, Esakky Suthagar, Kannan Annapoorna, Sridharan Sharmila et al.

    Pages 121-132

12. Novel Coordination Complexes of a Few Essential Trace Metals: Cytotoxic Properties and Lead Identification for Drug Development for Cancer

    • Anvarbatcha Riyasdeen, Rangasamy Loganathan, Mallayan Palaniandavar, Mohammad A. Akbarsha

    Pages 133-143

13. Why Is Gallbladder Cancer Common in the Gangetic Belt?

    • Ruhi Dixit, V. K. Shukla

    Pages 145-151

14. Stress and Cancer Risk: The Possible Role of Work Stress

    • Marcus James Fila

    Pages 153-162

15. Back Matter

    Pages 163-168

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Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory or population studies into clinical application to reduce incidence of cancer , morbidity and mortality. It is becoming increasingly evident that cancer is a preventable disease. The IVth International Symposium on Translational Cancer Research held in Udaipur, India in December 2011, discussed various aspects of the biological processes in cancer cells and approaches to cancer prevention. A few contributions from this meeting are presented in this book, providing an in depth analysis of data on cancer prevention and therapeutics. These contributions are either critical reviews or research reports. The topics discussed include evidence-based nutritional recommendations for cancer patients and survivors, risk factors such as stress, enrichment of tumour stem cells by anticancer drug treatment contributing to tumour recurrence and the mechanism of anticancer effects of various natural products. Chemosensitizing effect of curcumin, anti-cancer effect of products from neem, action of sulforaphane and cytotoxic effect of a number of novel synthetic coordination complexes of trace metals have been discussed. Novel molecular targets of angiogenesis and molecular basis of the gender bias to thyroid cancer have also been discussed . This book provides useful information on translational cancer research to clinicians and biomedical scientists.

• Antitumor Drugs
• Cancer Therapeutics
• Inflammation
• Natural Products
• Signalling Pathway

• Computational Biology & Bioinformatics, University of Kerala, Kariavattom, Trivandrum, India

  Perumana R. Sudhakaran

Prof. P .R Sudhakaran is a well-known biochemist who has made significant contribution in the area of vascular biology. His major areas of research include cell matrix interaction and cell signalling in both physiological and pathological conditions including atherosclerosis, angiogenesis and cancer. As Head of the Department of Biochemistry, University of Kerala Thiruvananthapuram, and the founder Dean of School of Biological Sciences, Central University of Kerala, Kasargod, India , he has contributed significantly to biochemical education in the country and is presently the Director, Kerala State Biotechnology Commission. Dr Sudhakaran has published over 130 original research articles in international journals and is a fellow of the National Academy of Medical Sciences (India).

Prof. M. Radhakrishna Pillai is a well-known cancer biologist, Director of the Rajiv Gandhi Centre for Biotechnology, National Research Institute of the Government of India in Thiruvananthapuram, Kerala . A fellow of both the Science and Medical academies of India and the Royal College of Pathologists, London, Professor Pillai has provided one of the most elaborate data bases of cellular and molecular processes occurring during epithelial tumor progression especially roles of human papilloma virus and apoptosis. His work on cellular manifestations of HPV infection particularly p53 gene inactivation, defective apoptosis and angiogenesis culminated in the description of a "condemned mucosa syndrome", which was well received in the scientific community. He has also demonstrated the existence of various HPV 16 subtypes showing how they are associated with various grades of cervical disease.

Prof. Oommen’s research contributions on comparative endocrinology in non-mammalian vertebrates led to establish identical pattern in these vertebrates as in homeotherms A new species (Gegeneophis primus) of caecilian and an extensive taxonomic revision of a hitherto poorly known rainforest caecilian species Ichthyophis longicephalus are his recent works. Scientists from Natural History Museum, London honored him by naming a caecilian after him (Ureaotyphlus oommeni). His research links with MD Anderson Cancer Center, USA in Cancer saw three International Symposia on Translational cancer Research . Dr .Oommen is active in science popularization as the President of Kerala Academy of Sciences. Currently, Prof. Oommen is the Chairman, Kerala State Biodiversity Board

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