Moyamoya Disease Update

1. Front Matter

   Pages i-xx

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Overview

      • Teiji Tominaga

      Pages 3-11

   3. Pathology of Moyamoya Disease

      • Kent Doi, Ken-ichiro Kikuta

      Pages 12-22

   4. Unilateral Moyamoya Disease

      • Chang-Wan Oh, Gyojun Hwang

      Pages 23-25

3. Epidemiology

   1. Front Matter

      Pages 27-27

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   2. Epidemiology of Moyamoya Disease

      • Koichi Oki, Haruhiko Hoshino, Norihiro Suzuki

      Pages 29-34

   3. Familial Moyamoya Disease

      • Joong-Uhn Choi

      Pages 35-37

4. Genetics

   1. Front Matter

      Pages 39-39

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   2. Overview

      • Shigeo Kure

      Pages 41-45

   3. Genetic Linkage Study

      • Shigeo Kure

      Pages 46-50

   4. Single Nucleotide Polymorphism and Moyamoya Disease

      • Hyun-Seung Kang, Kyu-Chang Wang

      Pages 51-53

   5. HLA Studies in Moyamoya Disease

      • Myoung Hee Park, Seok Ho Hong, Kyu-Chang Wang

      Pages 54-59

5. Pathophysiology I: Protein, Cell, and Immunology

   1. Front Matter

      Pages 61-61

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   2. Proteins, Cells, and Immunity in the Moyamoya Disease: An Overview

      • Seung-Ki Kim, Kyu-Chang Wang, Byung-Kyu Cho

      Pages 63-68

   3. Vascular Smooth Muscle Cell-Related Molecules and Cells

      • Yasushi Takagi

      Pages 69-72

   4. Ischemia/Angiogenesis-Related Molecules and Cells

      • Jin Hyun Kim, Seung-Ki Kim, Kyu-Chang Wang

      Pages 73-81

   5. Immunological Aspects of Moyamoya Disease

      • Ji Hoon Phi, Seung-Ki Kim, Kyu-Chang Wang, Byung-Kyu Cho

      Pages 82-86

6. Pathophysiology II: Hemodynamics, Biomechanical Aspect

   1. Front Matter

      Pages 87-87

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   2. Hemodynamics

      • Jeong Chul Kim, Eun Bo Shim

      Pages 89-98

Moyamoya disease (MMD) was first reported as a new entity among vascular disorders in 1957. Named for the abnormal vascular networks found around the occluded distal internal carotid artery, it is the most common pediatric cerebrovascular disease in East Asia. In recent years large amounts of data on MMD have been collected and important investigations have been carried out in Japan and Korea, even as the pathophysiology of the disease remains to be discovered. This monograph covers a diversity of topics and presents a systematic compilation of the data and current status of MMD in clinical practice and basic research. With contributions by more than 70 authors, the book includes sections on genetics, computational analysis of hemodynamic shear stress, new imaging techniques, and endovascular treatment of MMD, along with practical applications and future directions for gene and stem cell therapies. For neurosurgeons as well as neurologists and pediatricians, this volume will help lead to more efficient and informed management of MMD.

• MMD
• Moyamoya Disease
• PET
• SPECT
• anesthesia
• cerebrovascular disease
• cognition
• electroencephalography (EEG)
• magnetic resonance imaging (MRI)
• muscle
• neurosurgery
• pathophysiology
• positron emission tomography (PET)
• surgery
• surgical technique

From the reviews:

“This is an almost 400-page book on the current status of all things relating to Moyamoya disease (MMD) definition, etiology, status of research, diagnostic modalities, and treatment options. … Illustrative of all this material … are well done, sharp, and clear, with good legends and explanatory material. … Certainly, this is the definitive book for someone who wishes information on Moyamoya disease. It is quite complete, almost excessively so, and will undoubtedly remain a basic source for several years to come.” (Robert M. Arensman, Doody’s Review Service, June, 2010)

“Moyamoya Disease Update, edited by Cho and Tominaga, provides an excellent update of this recent progress and a comprehensive overview of all relevant aspects of the disease. … This book is an exciting and highly recommended update on moyamoya disease. In addition to the scientific and clinical information, the book clearly indicates that recent years have been substantial progress in our understanding of the disease.” (Peter Vajkoczy, The Lancet Neurology, Vol. 9, August, 2010)

• Department of Neurosurgery, Seoul National University College of Medicine Seoul National University Children's Hospital, Jongno-gu, Republic of Korea

  Byung-Kyu Cho

• Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Japan

  Teiji Tominaga

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