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The Biology of Krüppel-like Factors

  • Book
  • © 2009

Overview

Editors:
  1. Ryozo Nagai

    1. Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan

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  2. Scott L. Friedman

    1. Division of Liver Diseases, Mount Sinai School of Medicine, New York, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Masato Kasuga

    1. Research Institute, International Medical Center of Japan, Shinjuku-ku, Japan

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-viii
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  2. Overview

    1. Krüppel-like Factors: Ingenious Three Fingers Directing Biology and Pathobiology

      • Ryozo Nagai, Ichiro Manabe, Toru Suzuki
      Pages 3-18

  3. Molecular Control of Krüppel-like Factor Function

    1. Molecular Structures of Krüppel-like Factors

      • Toshio Nagashima, Fumiaki Hayashi, Takashi Umehara, Shigeyuki Yokoyama
      Pages 21-31

    2. Krüppel-like Factor Proteins and Chromatin Dynamics

      • Navtej S. Buttar, Gwen A. Lomberk, Gaurang S. Daftary, Raul A. Urrutia
      Pages 33-49

    3. Co-regulator Interactions in Krüppel-like Factor Transcriptional Programs

      • Richard C. M. Pearson, Briony H. A. Jack, Stella H. Y. Lee, Alister P. W. Funnell, Merlin Crossley
      Pages 51-64

  4. Krüppel-like Factors in Development and Differentiation

    1. Developmental Expression of Krüppel-like Factors

      • Yizeng Yang, Jonathan P. Katz
      Pages 67-82

    2. Expanded Role for EKLF/KLF1 Within the Hematopoietic Lineage

      • James J. Bieker
      Pages 83-93

    3. Roles of Krüppel-like Factors in Lymphocytes

      • Kensuke Takada, Kristin A. Hogquist, Stephen C. Jameson
      Pages 95-106

    4. Krüppel-like Factors in Gastrointestinal Tract Development and Differentiation

      • Marie-Pier Tétreault, Jonathan P. Katz
      Pages 107-119

    5. Gene Interactions Between Krüppel-like Factors in Development

      • Joyce A. Lloyd
      Pages 121-130

    6. Krüppel-like Factors in Stem Cell Biology

      • Masatsugu Ema, Satoru Takahashi, Yoshiaki Fujii-Kuriyama
      Pages 131-138

  5. Krüppel-like Factors in Organ Function and Disease

    1. Krüppel-like Factors and the Liver

      • Goutham Narla, Scott L. Friedman
      Pages 141-150

    2. Role of Krüppel-like Factor 15 in Adipocytes

      • Wataru Ogawa, Hiroshi Sakaue, Masato Kasuga
      Pages 151-157

    3. Krüppel-like Factors in the Heart

      • Daiji Kawanami, Saptarsi M. Haldar, Mukesh K. Jain
      Pages 159-171

    4. Krüppel-like Factors in the Vascular Endothelium

      • Guillermo García-Cardeña, Guadalupe Villarreal
      Pages 173-184

    5. Krüppel-like Factors KLF2, KLF4, and KLF5: Central Regulators of Smooth Muscle Function

      • Christopher W. Moehle, Gary K. Owens
      Pages 185-204

    6. Krüppel-like Factors in Cancers

      • Vincent W. Yang
      Pages 205-219

  6. Diagnostic and Therapeutic Applications of Krüppel-like Factors

    1. Krüppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer

      • Analisa DiFeo, Goutham Narla, John A. Martignetti
      Pages 223-244

    2. Drug Development and Krüppel-like Factors

      • Ichiro Manabe, Ryozo Nagai
      Pages 245-252

  7. Back Matter

    Pages 253-258
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Keywords

About this book

Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.

Editors and Affiliations

  • Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan

    Ryozo Nagai

  • Division of Liver Diseases, Mount Sinai School of Medicine, New York, USA

    Scott L. Friedman

  • Research Institute, International Medical Center of Japan, Shinjuku-ku, Japan

    Masato Kasuga

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