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  • Book
  • © 2011

Harnessing Biological Complexity

An Introduction to Computational Physiology

Editors:

  1. Taishin Nomura

    1. Mechanical Science and Bioengineering Graduate School of Engineering Science, Osaka University, Toyonaka, Japan

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  2. Yoshiyuki Asai

    1. The Center for Advanced Medical Engineering and Informatics, Osaka University, Toyonaka, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • This book aims to establish a seamless educational system for engineers and clinicians who play a key role as leaders in relevant fields, based on advanced knowledge in engineering, informatics, medicine, and clinical practices
  • The development of physiome and systems biology will change conventional medicine which has been based on experience and expectation into "predictive medicine
  • Includes supplementary material: sn.pub/extras

Part of the book series: A First Course in “In Silico Medicine” (FCISM, volume 1)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-x
    PDF

  2. Introduction

    • Taishin Nomura, Yoshiyuki Asai
    Pages 1-9

  3. Modeling Cellular Dynamics

    • Taishin Nomura, Yoshiyuki Asai
    Pages 11-81

  4. Dynamics of Cellular Networks

    • Taishin Nomura, Yoshiyuki Asai
    Pages 83-124

  5. Application of ISIDE to Create Models

    • Taishin Nomura, Yoshiyuki Asai
    Pages 125-194

  6. Key Concepts of insilicoML

    • Taishin Nomura, Yoshiyuki Asai
    Pages 195-216

  7. Back Matter

    Pages 217-222
    PDF
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About this book

The challenge for the biosciences in the twenty-first century is to integrate genome sequencing information into a better understanding of biology, physiology, and human pathology. Such attempts at integration are moving the world toward a new generation of bioscience and bioengineering, where biological, physiological, and pathological information from humans and other living animals can be quantitatively described in silico across multiple scales of time and size and through diverse hierarchies of organization — from molecules to cells and organs, to individuals. To "harness" such complexity, international communities of integrative bioscientists and bioengineers aim to establish frameworks and information infrastructures for describing biological structures and physiological functions on multiple scales of time and space. This textbook includes a public platform to describe physiological functions using mathematical equations and guides the reader to perform mathematical modeling and computer simulations, to combine existing models as well as to create new models. Accessible to biologists, physiologists, and students of the sciences, with illustrative details provided when necessary, this book seeks to achieve a systematic way of harnessing biological complexity. Sharing the databases among communities worldwide will help to find comprehensive answers to all the important questions.
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Keywords

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Editors and Affiliations

  • Mechanical Science and Bioengineering Graduate School of Engineering Science, Osaka University, Toyonaka, Japan

    Taishin Nomura

  • The Center for Advanced Medical Engineering and Informatics, Osaka University, Toyonaka, Japan

    Yoshiyuki Asai

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Bibliographic Information

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Buy it now

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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