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Birkhäuser

Imaging in Drug Discovery and Early Clinical Trials

  • Book
  • © 2005

Overview

Editors:
  1. Paul L. Herrling

    1. Novartis International AG, Basel, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  2. Alex Matter

    1. Novartis Institute for Tropical Diseases, Singapore, Singapore

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    You can also search for this editor in PubMed   Google Scholar

  3. Markus Rudin

    1. Institute for Biomedical Engineering, University of Zürich/ETH Zürich, Zürich, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  • Presents new essential technologies
  • Critical evaluation of new biomarkers
  • Regulatory issues and potential pitfalls are discussed

Part of the book series: Progress in Drug Research (PDR, volume 62)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
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  2. The drug discovery process

    • Paul L. Herrling
    Pages 1-14

  3. Imaging modalities: principles and information content

    • Tobias Schaeffter
    Pages 15-81

  4. Magnetic resonance and fluorescence based molecular imaging technologies

    • David Sosnovik, Ralph Weissleder
    Pages 83-115

  5. Studying molecular and cellular processes in the intact organism

    • Olivier Gheysens, Sanjiv S. Gambhir
    Pages 117-150

  6. Disease phenotyping: structural and functional readouts

    • R. Mark Henkelman, X. Josette Chen, John G. Sled
    Pages 151-184

  7. Evaluation of drug candidates: Efficacy readouts during lead optimization

    • Markus Rudin, Nicolau Beckmann, Martin Rausch
    Pages 185-255

  8. Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities

    • Mark W. Tengowski, John J. Kotyk
    Pages 257-278

  9. Pharmacokinetic studies with PET

    • Mats Bergström, Bengt Långström
    Pages 279-317

  10. Imaging bio-markers predictive of disease/therapy outcome: ischemic stroke and drug development

    • Janet C. Miller, A. Gregory Sorensen
    Pages 319-356

  11. Clinical drug evaluation using imaging readouts: regulatory perspectives

    • David S. Lester
    Pages 357-384

  12. Back Matter

    Pages 385-392
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Keywords

About this book

In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation. A chapter describes imaging biomarkers, their development, advantages and the potential pitfalls associated with their use. In the translation of imaging tools from animals to man regulatory issues have to be addressed, which are dealt with in a separate section.

The monograph provides a comprehensive overview on the role of imaging in drug discovery today and discusses major developments and trends both with regard to technologies and applications.

Editors and Affiliations

  • Novartis International AG, Basel, Switzerland

    Paul L. Herrling

  • Novartis Institute for Tropical Diseases, Singapore, Singapore

    Alex Matter

  • Institute for Biomedical Engineering, University of Zürich/ETH Zürich, Zürich, Switzerland

    Markus Rudin

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