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The Hereditary Basis of Rheumatic Diseases

  • Book
  • © 2006

Overview

Editors:
  1. Rikard Holmdahl

    1. Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, Lund, Sweden

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  • Deals extensively with the genetic basis and regulation of rheumatic diseases
  • Describes genetic studies of rheumatic diseases; analyzes their shared heredity; offers tools for understanding complexity
  • Provides an up-to-date overview of the field, written by leading experts
  • Addresses researchers and clinicians in rheumatology, inflammation research, immunology, and cell and molecular biology
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Genetics of joint inflammation — problems and possibilities

      • Rikard Holmdahl
      Pages 3-6

  3. Genetic studies on rheumatic diseases

    1. Front Matter

      Pages 7-7
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    2. The epidemiology of rheumatoid arthritis and the use of linkage and association studies to identify disease genes

      • Jane Worthington, Anne Barton, Sally L. John
      Pages 9-28

    3. Heterogeneity in rheumatoid arthritis based on expression analysis: towards personalised medicine

      • Cornelis L. Verweij, Tineke C. T. M. van der Pouw Kraan
      Pages 29-42

    4. Gene-based large scale LD-mapping of rheumatoid arthritis-associated genes

      • Ryo Yamada, Kazuhiko Yamamoto
      Pages 43-57

  4. Shared heredity of rheumatic diseases

    1. Front Matter

      Pages 59-59
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    2. Emerging relationships: rheumatoid arthritis and the PTPN22 associated autoimmune disorders

      • Peter K. Gregersen, Robert M. Plenge
      Pages 61-78

    3. Shared genes in rheumatic diseases, the role of PD1 and the RUNX genes in disease susceptibility

      • Marta E. Alarcón-Riquelme, Sergey V. Kozyrev
      Pages 79-88

    4. The role of B27 and other genes associated with ankylosing spondylitis

      • Joachim Sieper, Martin Rudwaleit
      Pages 89-104

  5. Tools for analysing complexity

    1. Front Matter

      Pages 105-105
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    2. Emerging tools for dissecting complex disease

      • Ulf D. Landegren
      Pages 107-117

    3. Expression analysis of rheumatic diseases, prospects and problems

      • Thomas Häupl, Andreas Grützkau, Joachim Grün, Andreas Radbruch, Gerd Burmester
      Pages 119-130

    4. The use of humanized MHC mouse strains for studies of rheumatic diseases

      • Kary A. Latham, Timothy D. Kayes, Zhaohui Qian, Edward F. Rosloniec
      Pages 131-146

    5. SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T-cells

      • Shimon Sakaguchi, Takeshi Takahashi, Hiroshi Hata, Hiroyuki Yoshitomi, Satoshi Tanaka, Keiji Hirota et al.
      Pages 147-159

    6. A genetic approach to select and validate new targets for treatment of rheumatic diseases

      • Peter J. Olofsson
      Pages 161-174

  6. Back Matter

    Pages 175-180
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Keywords

About this book

Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular tools. The volume is essential reading for researchers and clinicians from rheumatology, inflammation research, immunology, and cell and molecular biology.

Editors and Affiliations

  • Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, Lund, Sweden

    Rikard Holmdahl

Bibliographic Information

  • Book Title: The Hereditary Basis of Rheumatic Diseases

  • Editors: Rikard Holmdahl

  • Series Title: Progress in Inflammation Research

  • DOI: https://doi.org/10.1007/3-7643-7419-5

  • Publisher: Birkhäuser Basel

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Birkhäuser Basel 2006

  • Hardcover ISBN: 978-3-7643-7201-9Published: 19 April 2006

  • eBook ISBN: 978-3-7643-7419-8Published: 02 July 2006

  • Series ISSN: 1422-7746

  • Series E-ISSN: 2296-4525

  • Edition Number: 1

  • Number of Pages: IX, 182

  • Topics: Rheumatology, Immunology, Human Genetics, Cell Biology

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