Skip to main content
SpringerLink
Log in
Birkhäuser

NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics

  • Book
  • © 2006

Overview

Editors:
  1. Zofia Zukowska

    1. Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Giora Z. Feuerstein

    1. Wyeth Research, Collegeville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive state-of-the art review
  • Discusses the frontiers of NPY research and drug development
  • Points out new opportunities for medical intervention

Part of the book series: Experientia Supplementum (EXS, volume 95)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (19 chapters)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  3. NPY family of peptides, receptors and processing enzymes

    1. Front Matter

      Pages 5-5
      Download chapter PDF

    2. An overview of neuropeptide Y: pharmacology to molecular biology and receptor localization

      • Yvan Dumont, Rémi Quirion
      Pages 7-33

    3. Molecular ligand-receptor interaction of the NPY/PP peptide family

      • Nicole Merten, Annette G. Beck-Sickinger
      Pages 35-62

  4. Physiological and pathophysiological perspectives of the NPY family of peptides

    1. Front Matter

      Pages 63-63
      Download chapter PDF

    2. Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions

      • M. Verónica Donoso, Ana María Delpiano, J. Pablo Huidobro-Toro
      Pages 65-76

    3. NPY and NPY receptors: presence, distribution and roles in the regulation of the endocardial endothelium and cardiac function

      • Danielle Jacques, Sawsan Sader, Claudine Perreault, Dima Abdel-Samad
      Pages 77-87

    4. Neuropeptide Y and sympathetic control of vascular tone in hypertension

      • Thomas C. Westfall
      Pages 89-103

    5. Neuropeptide Y and the cerebral circulation

      • Lars Edvinsson
      Pages 105-112

    6. Neuropeptide Y and the heart: implication for myocardial infarction and heart failure

      • Giora Z. Feuerstein, Edward W. Lee
      Pages 113-122

    7. Role of neuropeptide Y in the regulation of kidney function

      • Joseph Winaver, Zaid Abassi
      Pages 123-132

    8. NPY and neuron-adipocyte interactions in the regulation of metabolism

      • L. Christine Turtzo, M. Daniel Lane
      Pages 133-141

    9. NPY and energy homeostasis: an opportunity for novel anti-obesity therapies

      • Douglas J. MacNeil, Akio Kanatani
      Pages 143-156

    10. Subjugation of hypothalamic NPY and cohorts with central leptin gene therapy alleviates dyslipidemia, insulin resistance, and obesity for life-time

      • Satya P. Kalra, Pushpa S. Kalra
      Pages 157-169

    11. NPY and bone

      • Susan J. Allison, Herbert Herzog
      Pages 171-182

    12. NPY in alcoholism and psychiatric disorders

      • Annika Thorsell, Rose-Marie Karlsson, Markus Heilig
      Pages 183-192

    13. Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis

      • Helen E. Scharfman, William P. Gray
      Pages 193-211

    14. NPY and extreme stress: lessons learned from posttraumatic stress disorder

      • Mary Ann Dutton, Edward W. Lee, Zofia Zukowska
      Pages 213-222
Back to top

Keywords

About this book

The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists which are in clinical development for obesity while NPY Y1 receptors are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders are also actively pursued.

This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders, written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.

Editors and Affiliations

  • Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC, USA

    Zofia Zukowska

  • Wyeth Research, Collegeville, USA

    Giora Z. Feuerstein

Bibliographic Information

  • Book Title: NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics

  • Editors: Zofia Zukowska, Giora Z. Feuerstein

  • Series Title: Experientia Supplementum

  • DOI: https://doi.org/10.1007/3-7643-7417-9

  • Publisher: Birkhäuser Basel

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Birkhäuser Basel 2006

  • Hardcover ISBN: 978-3-7643-7155-5Published: 17 November 2005

  • eBook ISBN: 978-3-7643-7417-4Published: 28 March 2006

  • Series ISSN: 1664-431X

  • Series E-ISSN: 2504-3692

  • Edition Number: 1

  • Number of Pages: X, 280

  • Topics: Biomedicine general

Publish with us

Policies and ethics

Back to top

Search

Navigation