Tetracyclines in Biology, Chemistry and Medicine

1. Front Matter

   Pages I-X

   PDF

2. Chemistry, biology and microbiologic action of tetracyclines

   1. Front Matter

      Pages 1-1

      PDF

   2. The chemistry and cellular biology of the tetracyclines

      • Mark L. Nelson

      Pages 3-63

   3. Proton and metal ion binding of tetracyclines

      • Siegfried Schneider

      Pages 65-104

3. Tetracycline-dependent gene regulation: A versatile tool for all organisms

   1. Front Matter

      Pages 105-105

      PDF

   2. Gene regulation by the tetracycline-inducible Tet repressor-operator system — molecular mechanisms at atomic resolution

      • Winfried Hinrichs, Christiane Fenske

      Pages 107-123

   3. Regulation of gene expression in yeast and plants by tetracycline-dependent regulatory systems

      • Elisabeth Pook

      Pages 125-137

   4. Tetracyclines in the control of gene expression in eukaryotes

      • Manfred Gossen, Hermann Bujard

      Pages 139-157

   5. Tetracycline-regulated gene expression to study oncogenes in vivo

      • Jeffrey E. Kudlow

      Pages 159-175

   6. Interactions of tetracyclines with RNA

      • Christian Berens

      Pages 177-196

4. Use of tetracyclines as non-antimicrobial medicinal agents

   1. Front Matter

      Pages 197-197

      PDF

   2. Biological, non-antibiotic properties of semi-synthetic and chemically modified tetracyclines — a structured, annotated bibliography

      • Robert A. Greenwald, Lome M. Golub

      Pages 199-217

   3. Tetracycline consumption in prehistory

      • George J. Armelagos, Kristi Kolbacher, Kristy Collins, Jennifer Cook, Maria Krafeld-Daugherty

      Pages 219-236

   4. Tetracycline treatment of periodontal disease: antimicrobial and non-antimicrobial mechanisms

      • Maria Emanuel Ryan, Danielle M. Baker

      Pages 237-265

   5. Inhibition of matrix metalloproteinases (MMPs) by tetracyclines

      • Roeland Hanemaaijer, Natascha van Lent, Timo Sorsa, Tuula Salo, YrjŐ, T. Konttinen et al.

      Pages 267-281

   6. Structure/function studies of doxycycline effects on matrix metalloproteinase activity and cartilage degeneration

      • N Gerald, Jr Smith, Karen A Hasty

      Pages 283-293

   7. Regulation of inflammatory mediators by tetracyclines

      • Mukundan G. Attur, Mandar N. Dave, Nirupama Mohandas, Indravadan R. Patel, Steven B. Abramson, Ashok R. Amin

      Pages 295-310

   8. Tetracyclines and autoimmunity

      • Helena Marzo-Ortega, Roland M Strauss, Paul Emery

      Pages 311-324

   9. Tetracycline photodynamics

      • Brad R. Zerler

      Pages 325-332

5. Back Matter

   Pages 333-336

   PDF

The tetracyclines have an illustrious history as therapeutic agents which dates back over half a century. Initially discovered as an antibiotic in 1947, the four­ ringed molecule has captured the fancy of chemists and biologists over the ensuing decades. Of further interest, as described in the chapter by George Armelagos, tetracyclines were already part of earlier cultures, 1500-1700 years ago, as revealed in traces of drug found in Sudanese Nubian mummies. The diversity of chapters which this book presents to the reader should illus­ trate the many disciplines which have examined and seen benefits from these fascinating natural molecules. From antibacterial to anti-inflammatory to anti­ autoimmunity to gene regulation, tetracyclines have been modified and redesigned for various novel properties. Some have called this molecule a biol­ ogist's dream because of its versatility, but others have seen it as a chemist's nightmare because of the synthetic chemistry challenges and "chameleon-like" properties (see the chapter by S. Schneider).

• Antibiotika
• RNA
• antibiotics
• biology
• cancer
• chemistry
• diseases
• eukaryote
• gene expression
• genes
• infectious disease
• molecular mechanisms
• oncogene
• protein
• regulation

• Paratek Pharmaceuticals, Boston, USA

  Mark Nelson

• Lehrstuhl für Mikrobiologie, Friedrich-Alexander Universität, Erlangen, Germany

  Wolfgang Hillen

• Division of Rheumatology, Long Island Jewish Medical Center, New Hyde Park, USA

  Robert A. Greenwald

Policies and ethics