Principles of Immunopharmacology

1. Front Matter

   Pages i-xxiii

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2. Mechanisms of immunity

   1. Front Matter

      Pages 1-1

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   2. Hematopoiesis, including lymphocyte development and maturation

      • Valerie F.J. Quesniaux, Julian D. Down, Henk-Jan Schuurman

      Pages 3-17

   3. T cell-mediated immunity

      • Sergey G. Apasov, Michail V. Sitkovsky

      Pages 19-28

   4. Antibody diversity and B cell-mediated immunity

      • Ger T. Rijkers, Lisette van de Corput

      Pages 29-44

   5. Cytokines

      • Klaus Resch

      Pages 45-61

   6. Innate immunity — phagocytes, natural killer cells and the complement system

      • Dirk Roos, Hergen Spits, C. Erik Hack

      Pages 63-80

   7. Inflammatory mediators and intracellular signalling

      • Richard Korbut, Tomasz J. Guzik

      Pages 81-103

   8. Immune response in human pathology: infections caused by bacteria, viruses, fungi, and parasites

      • Jan Verhoef, Harm Snippe

      Pages 105-115

   9. Immune response in human pathology: hypersensitivity and autoimmunity

      • Jacques Descotes, Thierry Vial

      Pages 117-127

   10. Cancer immunity

       • Jan W. Gratama, Reno Debets, Ralph A. Willemsen

       Pages 129-148

   11. Neuroimmunoendocrinology

       • Douglas A. Weigent, J. Edwin Blalock

       Pages 149-159

3. Immunodiagnosis

   1. Front Matter

      Pages 161-161

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   2. Antibody detection

      • Klaus Hermann, Markus Ollert, Johannes Ring

      Pages 163-170

   3. Immunoassays

      • Michael J. O’Sullivan

      Pages 171-181

   4. Flow cytometry

      • John F. Dunne, Holden T. Maecker

      Pages 183-196

   5. Gene arrays

      • Barbara Schaffrath, Andreas Bosio

      Pages 197-211

   6. Proteomics and applications within the drug development pipeline

      • René Houtman, Ian Humphery-Smith

      Pages 213-227

4. Immunotherapeutics

   1. Front Matter

      Pages 229-229

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   2. Vaccines

      • Wim Jiskoot, Gideon F.A. Kersten

      Pages 231-245

The rapid developments in immunology in recent immunomodulatory drugs can be distinguished years have dramatically expanded our knowledge of from their beneficial therapeutic effects. mammalian host defence mechanisms. The molecu- Currently,it is only possible to obtain an overview lar mechanisms of cellular interactions during of these various aspects of immunopharmacology immune responses have been unravelled,the intra- by reading a range of immunological,pharmacol- cellular responses involved in signal transduction ical,diagnostic and toxicological literature. Good delineated and an ever-increasing number of soluble immunological textbooks are available, while mediators of immune and inflammatory reponses immunopharmacology is covered mainly in terms of have been discovered. the inflammatory response. Principles of Immuno- The initial result of this explosion of knowledge pharmacology is intended to provide for the first time has been to provide the researcher and the clinician in a single volume a basic understanding of with an arsenal of diagnostic tools with which the immunological mechanisms,a review of important immunological bases of disease processes can be immunodiagnostic tools and a description of the investigated. This has made disease diagnosis much main pharmacological agents which modify the more precise,enabling the physician to tailor therapy immune response,together with an introduction to much more closely to the individual patient’s needs. immunotoxicology. As such we hope that it will be However,better understanding of disease processes useful as a reference text for physicians,researchers only provides a gradual improvement in therapy. This and students with a rudimentary knowledge of is because the new molecular targets that have beenimmunology.

• Asthma
• Immunity
• Immunodiagnosis
• Immunology
• Immunotherapeutics
• Immunotoxicology
• Pharmacology
• infections
• infectious diseases

"It has exhausted all problems of immunopharmacology as never any other book has realized previously." (Cellular and Molecular Biology)

• Faculty of Pharmacy, Department of Pharmacology and Pathophysiology, Utrecht, The Netherlands

  Frans P. Nijkamp

• PLIVA Research Institute Ltd., Zagreb, Croatia

  Michael J. Parnham

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