Overview
- Editors:
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James D. Winkler
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Oncology Research, Smith Kline Beecham Pharmaceuticals, King of Prussia, USA
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Table of contents (13 chapters)
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- Cynthia L. Mann, John A. Cidlowski
Pages 7-17
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- Floyd H. Chilton III, Floyd H. Chilton Jr., Carl E. Clay, Anthony Trimboli, Alfred N. Fonteh
Pages 19-38
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- John Savill, Christopher Haslett
Pages 53-84
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- Don J. Park, Mark J. Koury
Pages 85-99
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- Martin Lotz, Sanshiro Hashimoto, Robert Ochs, Klaus Kühn
Pages 101-119
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- David A. Norris, Yiqun Shellman, Gary A. Bellus
Pages 121-147
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- Paul P. Tak, Gary S. Firestein
Pages 149-162
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- Mark E. Nuttall, Maxine Gowen, Michael W. Lark
Pages 163-179
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- Gwan Gyu Song, Martin Fleck, Jianguo Wu, Hui-Chen Hsu, Tong Zhou, John D. Mountz
Pages 181-212
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- Victoria Y. Wong, Shujath M. Ali, David P. Brooks
Pages 227-238
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Back Matter
Pages 239-244
About this book
Apoptosis is a form of cell death that occurs in a controlled manner and is generally noninflammatory in nature. Apoptosis, or programmed cell death, implies a cell death that is part of a normal physiological process of pruning of unneeded cells. However, many disease conditions utilize apoptosis for pathological ends, resulting in inappropriate cell death and tissue destruction. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases.
Editors and Affiliations
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Oncology Research, Smith Kline Beecham Pharmaceuticals, King of Prussia, USA
James D. Winkler
