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Birkhäuser

Microsystem Technology

A Powerful Tool for Biomolecular Studies

  • Book
  • © 1999

Overview

Editors:
  1. J. M. Köhler

    1. Institut für Physikal, Hochtechnologie Jena, Jena, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. T. Mejevaia

    1. Jena, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. H. P. Saluz

    1. Hans-Knöll-Institut für Naturstofforschung e.V., Jena, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Biomethods (BIOMETHODS)

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Table of contents (23 chapters)

  1. Front Matter

    Pages I-XXIV
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  2. Molecular building principles in nature

    • J. Michael Koehler, Hans Peter Saluz
    Pages 1-15

  3. Robotic equipment and microsystem technology in biological research

    • Holger Eickhoff, Igor Ivanov, Markus Kietzmann, Elmar Maier, Markus Kalkum, David Bancroft et al.
    Pages 17-30

  4. Components and systems for microliquid handling

    • Steffen Howitz
    Pages 31-73

  5. Nanotiterplates for screening and synthesis

    • Günther Mayer, Klaus Wohlfart, Andreas Schober, J. Michael Köhler
    Pages 75-128

  6. Chip technology for micro-separation

    • Andrew J. de Mello, Andreas Manz
    Pages 129-177

  7. Rapid multisample PCR in miniaturized ultrathin-walled microwell plates

    • Alexander N. Tretyakov, Rimma A. Pantina, Oleg K. Kaboev, Hans Peter Saluz
    Pages 179-187

  8. Generation of large libraries

    • Carola Burgtorf, Hans Lehrach
    Pages 189-223

  9. Generation and screening of solution-phase synthetic peptide combinatorial libraries

    • Andrew Wallace, Kenneth S. Koblan, Riccardo Cortese, Jackson B. Gibbs, Antonello Pessi
    Pages 225-240

  10. Using oligonucleotide probe arrays to access genetic diversity

    • R. J. Lipshutz, D. Morris, M. Chee, E. Hubbell, M. J. Kozal, N. Shah et al.
    Pages 241-254

  11. Generation of libraries by print technologies

    • Eugen Ermantraut, Sefan Wölfl, Hans Peter Saluz
    Pages 255-264

  12. Synthesis and screening of bead-based libraries

    • Dirk Vetter
    Pages 265-277

  13. Sensors for biomolecular studies

    • Jan Rickert, Thomas Wessa, Wolfgang Göpel
    Pages 279-310

  14. Fluorescence detection of single molecules applicable to small volume assays

    • Jörg Enderlein, W. Patrick Ambrose, Peter M. Goodwin, Richard A. Keller
    Pages 311-329

  15. Fluorescence correlation spectrometry (FCS): Measuring biological interactions in microstructures

    • Gabriele Gradl, Rolf Guenther, Silvia Sterrer
    Pages 331-351

  16. Scanning force microscopy: A microstructured device for imaging, probing, and manipulation of biomolecules at the nanometer scale

    • Wolfgang Fritzsche
    Pages 353-370

  17. DNA resequencing, mutation detection and gene expression analysis by oligonucleotide microchips

    • Andres Metspalu, John M. Shumaker
    Pages 371-397

  18. Miniaturized arrays for DNA analysis

    • Maryanne J. O’Donnell, Hubert Köster
    Pages 399-415

  19. Manipulation of particles, cells and liquid droplets by high frequency electric fields

    • Thomas Schnelle, Torsten Müller, Günter Fuhr
    Pages 417-452

  20. Optical trapping and manipulation

    • Karl Otto Greulich
    Pages 453-474
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Keywords

About this book

Biomolecular studies are the trial of Man to understand how Nature manages information at the molecular level. The understanding of molecular informa­ tion handling in nature is essential for the molecular optimization in chem­ istry, molecular biology, molecular pharmacology and therefore - as an ex­ ample - for the development of specifically acting drugs. The famous recent method of technical information management is digital electronics. Over the past few years, evidence has arisen that computerized and molecular information managements have many similar and overlapping aspects. For example, both technology and nature use digitized information and both use small structures for the efficient handling of information. Furthermore, they optimize their processes in order to gain a maximum of information with a minimum of invested energy. During the last two decades, novel experimental techniques in biomolec­ ular sciences have paved the way for artificial biomolecular optimization. In the same time interval, the progress of micro system technology has been extended from the field of digital electronics and sensing to micro liquid hand­ ling, and the field of chip-supported substance handling began. It appears that the "marriage" of physical micro technology and molecular processing will be consummated soon. The contact of both fields has been realized in for ex­ ample DNA chips. Such connections will also become relevant in additional fields in the near future. Biomolecular investigations are the first to profit from these fast growing scientific and technical connections between micro systems and molecular sciences.

Editors and Affiliations

  • Institut für Physikal, Hochtechnologie Jena, Jena, Germany

    J. M. Köhler

  • Jena, Germany

    T. Mejevaia

  • Hans-Knöll-Institut für Naturstofforschung e.V., Jena, Germany

    H. P. Saluz

Bibliographic Information

  • Book Title: Microsystem Technology

  • Book Subtitle: A Powerful Tool for Biomolecular Studies

  • Editors: J. M. Köhler, T. Mejevaia, H. P. Saluz

  • Series Title: Biomethods

  • DOI: https://doi.org/10.1007/978-3-0348-8817-2

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 1999

  • Hardcover ISBN: 978-3-7643-5774-0Published: 01 June 1999

  • Softcover ISBN: 978-3-0348-9784-6Published: 16 October 2012

  • eBook ISBN: 978-3-0348-8817-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXIV, 581

  • Topics: Life Sciences, general, Biomedicine general

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