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Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo

  • Book
  • © 1996

Overview

Editors:
  1. David Raeburn

    1. Discovery Biology, Rhône-Poulenc Rorer Ltd Dagenham Research Centre, Essex, England

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  2. Mark A. Giembycz

    1. Department of Thoracic Medicine, National Heart and Lung Institute Imperial College of Science, Technology and Medicine, London, England

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Respiratory Pharmacology and Pharmacotherapy (RPP)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-VIII
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  2. Measurement of Airways Smooth Muscle Responsiveness in Animals

    • Steve Webber, Jan-Anders Karlsson
    Pages 1-25

  3. Methods of Drug Administration to the Lung in Animals

    • Stephen L. Underwood, David Raeburn
    Pages 27-50

  4. PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs

    • Aileen A. Y. Milne, Adriano G. Rossi, Ian D. Chapman
    Pages 51-73

  5. Antigen-Induced Bronchial Hyperreactivity in Rats

    • James G. Martin, Hideyasu Mishima
    Pages 75-93

  6. Ozone-Induced Bronchial Hyperreactivity

    • Wil H. M. Stevens, Paul M. O’Byrne
    Pages 95-119

  7. Virus-Induced Bronchial Hyperreactivity

    • David B. Jacoby
    Pages 121-145

  8. The Rabbit Model of Asthma and the Late Asthmatic Response

    • Caroline M. Herd, Clive P. Page
    Pages 147-169

  9. The Sheep as a Model of the Late Asthmatic Response

    • William M. Abraham
    Pages 171-189

  10. Primate Models of Asthma

    • Claudia R. Turner, John W. Watson
    Pages 191-223

  11. The Sensitized Pig Model of Asthma

    • Adrian Tomkinson
    Pages 225-240

  12. Transgenic Animals and the Modelling of Asthma

    • Robert Schilz, Jack A. Elias
    Pages 241-274

  13. Back Matter

    Pages 275-276
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Keywords

About this book

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

Editors and Affiliations

  • Discovery Biology, Rhône-Poulenc Rorer Ltd Dagenham Research Centre, Essex, England

    David Raeburn

  • Department of Thoracic Medicine, National Heart and Lung Institute Imperial College of Science, Technology and Medicine, London, England

    Mark A. Giembycz

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