Advances in Research on Neurodegeneration

1. Front Matter

   Pages I-VII

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2. Huntington disease: new insights on the role of huntingtin cleavage

   • C. L. Wellington, B. R. Leavitt, M. R. Hayden

   Pages 1-17

3. PARKIN as a pathogenic gene for autosomal recessive juvenile parkinsonism

   • N. Shimizu, S. Asakawa, S. Minoshima, T. Kitada, N. Hattori, H. Matsumine et al.

   Pages 19-30

4. Autosomal-dominantly inherited forms of Parkinson’s disease

   • T. Gasser

   Pages 31-40

5. Role of anti-apoptotic Bcl-2 protein in spinal muscular atrophy

   • Y. Tsujimoto

   Pages 41-52

6. Subcellular localization of α-synuclein in primary neuronal cultures: effect of missense mutations

   • P. J. McLean, S. Ribich, B. T. Hyman

   Pages 53-63

7. Roles of Aβ and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease

   • Y.-H. Suh, H.-S. Kim, J. P. Lee, C. H. Park, S.-J. Jeong, S.-S. Kim et al.

   Pages 65-82

8. Iron chelating, antioxidant and cytoprotective properties of dopamine receptor agonist; apomorphine

   • M. B. H. Youdim, M. Gassen, A. Gross, S. Mandel, E. Grünblatt

   Pages 83-96

9. The motor circuit of the human basal ganglia reconsidered

   • P. Foley, P. Riederer

   Pages 97-110

10. Involvement of endogenous N-methyl(R)salsolinol in Parkinson’s disease: induction of apoptosis and protection by (-)deprenyl

    • M. Naoi, W. Maruyama, T. Takahashi, Y. Akao, Y. Nakagawa

    Pages 111-121

11. The myelin oligodendrocyte glycoprotein (MOG): a model for antibody-mediated demyelination in experimental autoimmune encephalomyelitis and multiple sclerosis

    • A. Stefferl, U. Brehm, C. Linington

    Pages 123-133

12. Role of caspase-1 subfamily in cytotoxic cytokine-induced oligodendrocyte cell death

    • S. Hisahara, R. Takano, S. Shoji, H. Okano, M. Miura

    Pages 135-142

13. Cytokines in Parkinson’s disease

    • T. Nagatsu, M. Mogi, H. Ichinose, A. Togari

    Pages 143-151

14. Apoptosis as a general cell death pathway in neurodegenerative diseases

    • D. Offen, H. Elkon, E. Melamed

    Pages 153-166

15. Dentatorubral-pallidoluysian atrophy (DRPLA)

    • S. Tsuji

    Pages 167-180

16. Gene therapy of Parkinson’s disease using Adeno-Associated Virus (AAV) vectors

    • K. Ozawa, D.-S. Fan, Y. Shen, S. Muramatsu, K. Fujimoto, K. Ikeguchi et al.

    Pages 181-191

17. Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy

    • S. Pouly, J. P. Antel, U. Ladiwala, J. Nalbantoglu, B. Becher

    Pages 193-203

18. Optic-spinal form of multiple sclerosis and immune-mediated myelopathy in Japan

    • K. Fujihara, I. Nakashima, Y. Itoyama

    Pages 205-214

We organized the Seventh International Winter Conference on Neurodegeneration and Neuroinflammation in a small town of Karuizawa in Nagano Prefecture in Japan on January 20 to 22, 1999. Karuizawa is a nice summer as well as winter resort close to the place for winter Olympic game in the year of 1998. Over 40 scientists gathered together and made hot discussion. Neurodegeneration and neuroinflammation are two major and important neurologic disorders, in which satisfactory neuroprotective and neurorestorative treatment is not available yet. For this purpose, understanding of molecular mechanisms of neuronal cell death in these two disorders is imperative. Recently, pathologic processes common to these two groups of disorders have been identified such as the involvement of inflammatory changes, microglia, cytokines, and apoptosis. We intended to involve scientists working in these two major fields together to participate in hot and fruitful discussion for the understanding of neuronal death and for developing newer methods of treatment. The science is progressing so rapidly today and we are working in a very narrow specialized area. Sometimes, we are ignorant about important discoveries in other fields. This conference was a nice opportunity for scien­ tists working different areas to meet together and to exchange their experi­ ence. This volume is the proceedings of this Winter Conference.

• Alzheimer's Disease
• Multiple Sclerosis
• Neurodegeneration
• Neuroinflammation
• Parkinson
• Parkinson's Disease
• Spinocerebellar degeneration
• dopamine
• gene therapy

• Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

  Y. Mizuno

• Neurodegenerative Disorders Centre, Faculty of Medicine, University Hospital, Vancouver, Canada

  D. B. Calne

• Clinical Research, Schering AG, Berlin, Federal Republic of Germany

  R. Horowski

• Department of Neurology, University of Innsbruck, Austria

  W. Poewe

• Department of Psychiatry, University of Würzburg, Federal Republic of Germany

  P. Riederer

• Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel

  M. B. H. Youdim

Policies and ethics