Developmental Aspects of the Lymphatic Vascular System

1. Front Matter

   Pages i-xii

   PDF

2. Introductory Remarks

   • Friedemann Kiefer, Stefan Schulte-Merker

   Pages 1-4

3. Transcriptional Control of Lymphatic Endothelial Cell Type Specification

   • Ying Yang, Guillermo Oliver

   Pages 5-22

4. Mechanosensing in Developing Lymphatic Vessels

   • Lara Planas-Paz, Eckhard Lammert

   Pages 23-40

5. Plasticity of Airway Lymphatics in Development and Disease

   • Li-Chin Yao, Donald M. McDonald

   Pages 41-54

6. Regulation of Lymphatic Vasculature by Extracellular Matrix

   • Sophie Lutter, Taija Makinen

   Pages 55-65

7. Interplay of Mechanotransduction, FOXC2, Connexins, and Calcineurin Signaling in Lymphatic Valve Formation

   • Amélie Sabine, Tatiana V. Petrova

   Pages 67-80

8. Development of Secondary Lymphoid Organs in Relation to Lymphatic Vasculature

   • Serge A. van de Pavert, Reina E. Mebius

   Pages 81-91

9. Platelets in Lymph Vessel Development and Integrity

   • Steve P. Watson, Kate Lowe, Brenda A. Finney

   Pages 93-105

10. Interactions of Immune Cells and Lymphatic Vessels

    • Raghu P. Kataru, Yulia G. Lee, Gou Young Koh

    Pages 107-118

11. Lymphatic Vessels in the Development of Tissue and Organ Rejection

    • Deniz Hos, Claus Cursiefen

    Pages 119-141

12. The Role of Neuropilin-1/Semaphorin 3A Signaling in Lymphatic Vessel Development and Maturation

    • Alexandra M. Ochsenbein, Sinem Karaman, Giorgia Jurisic, Michael Detmar

    Pages 143-152

13. A Fisheye View on Lymphangiogenesis

    • Andreas van Impel, Stefan Schulte-Merker

    Pages 153-165

14. Visualization of Lymphatic Vessel Development, Growth, and Function

    • Cathrin Pollmann, René Hägerling, Friedemann Kiefer

    Pages 167-186

15. Clinical Disorders of Primary Malfunctioning of the Lymphatic System

    • Carlo Bellini, Raoul CM Hennekam

    Pages 187-204

The book focuses on the lymphatic vascular system from a developmental biologist’s point of view. It provides an overview on the many recent advances in understanding the development of lymphatic vessels, using advanced genetic models in conjunction with state of the art imaging. For each chapter a synopsis is provided, highlighting the main points in a concise manner. The book is intended for professors and researchers in vascular biology, angiogenesis research and developmental biology. It furthermore offers an excellent basis for entry level researchers and newcomers to this field, as well as for teachers, graduate students, advanced science and medical students.

• Lymph nodes
• Lymph vessels
• Lymphangiogenesis
• Lymphatic endothelial cell
• Lymphatics

• MPI for Molecular Biomedicine, Münster, Germany

  Friedemann Kiefer

• Hubrecht Institute, Utrecht, The Netherlands

  Stefan Schulte-Merker

Friedemann Kiefer is group leader at the Max Planck Institute for Molecular Biomedicine in Münster, Germany and Adjunct Professor at the Medical Faculty of the University of Münster. Stefan Schulte-Merker is group leader and Professor of Molecular Developmental Biology at the Hubrecht Institute in Utrecht, The Netherlands.

Policies and ethics