Metal Ions in Neurological Systems

1. Front Matter

   Pages i-xiv

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2. Brain iron metabolism and its perturbation in neurological diseases

   • Robert R. Crichton, David T. Dexter, Roberta J. Ward

   Pages 1-15

3. Brain changes in iron loading disorders

   • Elizabeth Milward, Bulent Acikyol, Brianna Bassett, Evan Williams, Ross Graham, Roheeth Delima et al.

   Pages 17-29

4. The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson’s disease

   • Irmgard Paris, Juan Segura-Aguilar

   Pages 31-39

5. Iron, cysteine and neurodegeneration during Parkinson’s disease

   • Eleni Siakkou, Guy N. L. Jameson

   Pages 41-46

6. Copper uptake and trafficking in the brain

   • Guido Crisponi, Valeria Marina Nurchi, Clara Gerosa, Daniela Fanni, Sonia Nemolato, Gavino Faa

   Pages 47-63

7. Prion diseases and manganism

   • Yuzo Nishida

   Pages 65-76

8. Metal ions and beta amyloid: conformational modifications and biological aspects

   • Alberto Granzotto, Paolo Zatta

   Pages 77-83

9. Beta-amyloid toxicity increases with hydrophobicity in the presence of metal ions

   • Alberto Granzotto, Silvia Bolognin, Janez Scancar, Radmila Milacic, Paolo Zatta

   Pages 85-94

10. Aluminium in the human brain

    • Christopher Exley, Emily R. House

    Pages 95-101

11. Aluminium-dependent human diseases and chelating properties of aluminium chelators for biomedical applications

    • Valeria Marina Nurchi, Guido Crisponi, Valerio Bertolasi, Gavino Faa, Maurizio Remelli

    Pages 103-123

12. Aluminum increases toxic effects of amyloid β-peptides on the human erythrocyte membrane and molecular models

    • Mario Suwalsky, Pedro L. Hernandez, Carlos P. Sotomayor

    Pages 125-135

13. Oxidative stress in neurodegeneration: targeting mitochondria as a therapeutic aid

    • Elena Gaggelli, Gianni Valensin

    Pages 137-161

14. The chemical mechanism of oxidative stress by copper(II) and iron(III) ions in several neurodegenerative disorders

    • Yuzo Nishida

    Pages 163-172

15. Metal ion roles and responses in the CNS under toxic organophosphonate exposure: traces of understanding and various open questions

    • Olga G. Tsay, Kibong Kim, David G. Churchill

    Pages 173-176

16. Heavy metals, behavior, and neurodegeneration: using Caenorhabditis elegans to untangle a can of worms

    • Samuel Caito, Michael Aschner

    Pages 177-187

17. The effect of point mutations on copper(II) complexes with peptide fragments encompassing the 106–114 region of human prion protein

    • Csilla Kállay, Ildikó Turi, Sarolta Timári, Zoltán Nagy, Daniele Sanna, Giuseppe Pappalardo et al.

    Pages 189-197

18. Interactions of pyridinecarboxylic acid chelators with brain metal ions: Cu(II), Zn(II), and Al(III)

    • Éva Sija, Annalisa Dean, Tamás Jakusch, Valerio B. Di Marco, Alfonso Venzo, Tamás Kiss

    Pages 199-210

19. Spatially resolved imaging methods to probe metals in the brain: from subcellular to organ level

    • Sylvain Bohic, Dominic Hare, Alexia Daoust, Peter Cloetens, Emmanuel L. Barbier

    Pages 211-222

20. ICP-MS for the neurodegenerative and brain sciences

    • Yonghwang Ha, Olga G. Tsay, David G. Churchill

    Pages 223-238

Metal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically all neurodegenerative disorders by inducing disease via the death of neurons. Managing metal ions in the brain could therefore be an important strategy in the search for therapeutic agents used in the treatment of neurodegenerative diseases. This new title gives an overview to key topics in the area of metal ions in the brain. It focuses on the role of metal ions in neurological systems by describing their advantageous functions as well as their poisonous features. It is therefore of interest for scientists in biochemistry and biophysics, physiology, toxicology as well as for physicians focused on this topic.

• metal ions
• metalloproteins
• neurological systems

• , Institute of Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria

  Wolfgang Linert

• Faculty of Chemistry, University of Wroclaw, Wroclaw, Poland

  Henryk Kozlowski

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