Overview
- Editors:
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Marina V. Rodnina
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Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
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Wolfgang Wintermeyer
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Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
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Rachel Green
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Howard Hughes Medical Institute Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, USA
- First ribosome book since 2001
- Nobel Prize Chemistry 2009 - The Ribosome
- Includes chapters of all three Nobel Prize winners
- Comprehensive in scope
- Includes supplementary material: sn.pub/extras
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Table of contents (33 chapters)
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Ribosome structure
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- C. Axel Innis, Gregor Blaha, David Bulkley, Thomas A. Steitz
Pages 31-43
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- Lasse B. Jenner, Natalia Demeshkina, Gulnara Yusupova, Marat Yusupov
Pages 45-55
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- Steven T. Gregory, Hasan Demirci, Jennifer F. Carr, Riccardo Belardinelli, Jill R. Thompson, Dale Cameron et al.
Pages 57-64
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- Jack A. Dunkle, Jamie H. D. Cate
Pages 65-73
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- Adam Ben-Shem, Lasse B. Jenner, Gulnara Yusupova, Marat Yusupov
Pages 75-81
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- Rajendra K. Agrawal, Manjuli R. Sharma, Aymen Yassin, Indrajit Lahiri, inda L. Spremulli
Pages 83-96
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- Petr V. Sergiev, Anna Y. Golovina, Irina V. Prokhorova, Olga V. Sergeeva, Ilya A. Osterman, Mikhail V. Nesterchuk et al.
Pages 97-110
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Recruiting the ribosome for translation
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Front Matter
Pages 111-111
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- Angelita Simonetti, Stefano Marzi, Alexander G. Myasnikov, Jean-François Ménétret, Bruno P. Klaholz
Pages 113-128
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- Michael Y. Pavlov, Suparna Sanyal, Måns Ehrenberg
Pages 129-141
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- Claudio O. Gualerzi, Anna Maria Giuliodori, Anna Brandi, Fabio Di Pietro, Lolita Piersimoni, Attilio Fabbretti et al.
Pages 143-154
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- Sarah F. Mitchell, Sarah E. Walker, Vaishnavi Rajagopal, Colin Echeverría Aitken, Jon R. Lorsch
Pages 155-169
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- Andrey V. Pisarev, Maxim A. Skabkin, Vera P. Pisareva, Olga V. Skabkina, Christopher U. T. Hellen, Tatyana V. Pestova
Pages 171-185
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Decoding, fidelity, and peptidyl transfer
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Front Matter
Pages 187-187
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- Jared M. Schrader, Margaret E. Saks, Olke C. Uhlenbeck
Pages 189-198
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About this book
The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.
About the editors
Dr. Marina V. Rodnina
Prof. Dr. Wolfgang Wintermeyer
MPI for Biophysical Chemistry, Dept. of Physical Biochemistry, Goettingen, Germany
Dr. Rachel Green
Dept. of Molecular Biology and Genetics, Investigator, Howard Hughes Medical Institute,
Johns Hopkins University School of Medicine, Baltimore, MD, USA
