The Blood Brain Barrier (BBB)

1. Front Matter

   Pages i-vii

   PDF

2. The Blood–Brain Barrier: An Introduction to Its Structure and Function

   • Anne Mahringer, Melanie Ott, Gert Fricker

   Pages 1-20

3. In Vivo Approaches to Assessing the Blood–Brain Barrier

   • Margareta Hammarlund-Udenaes

   Pages 21-48

4. ABC Transporters at the Blood–Brain Barrier

   • David S. Miller

   Pages 49-69

5. Nanoparticles as Blood–Brain Barrier Permeable CNS Targeted Drug Delivery Systems

   • Andreas M. Grabrucker, Resham Chhabra, Daniela Belletti, Flavio Forni, Maria Angela Vandelli, Barbara Ruozi et al.

   Pages 71-89

6. Blood–Brain Barrier and Stroke

   • David Fernández-López, Zinaida S. Vexler

   Pages 91-116

7. Inflammation at the Blood–Brain Barrier in Multiple Sclerosis

   • Mark R. Mizee, Ruben van Doorn, Alexandre Prat, Helga E. de Vries

   Pages 117-142

8. Drug Delivery Across the Blood–Brain Barrier with Focused Ultrasound and Microbubbles

   • Stephen Meairs

   Pages 143-158

9. Back Matter

   Pages 159-163

   PDF

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

• Alzheimer
• BBB
• blood brain barrier
• epilepsia
• stroke

• Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Heidelberg, Germany

  Gert Fricker

• Dept. for Pharmaceutical Technology and Pharmacology, Institute für Pharmacy and Molecular Biotechnology, Heidelberg, Germany

  Melanie Ott, Anne Mahringer

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