Tacrolimus Ointment

1. Front Matter

   Pages I-XX

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2. Atopic Dermatitis

   1. Front Matter

      Pages 1-1

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   2. Epidemiology of Atopic Dermatitis

      • T. L. Diepgen

      Pages 3-21

   3. The Pathogenesis of the Atopic Eczema/Dermatitis Syndrome

      • N. Novak, T. Bieber

      Pages 23-45

   4. Detecting, Diagnosing and Grading Atopic Dermatitis

      • J. M. Hanifin

      Pages 47-61

   5. Current Treatment of Atopic Dermatitis

      • J. D. Bos

      Pages 63-77

3. Development of Tacrolimus Ointment

   1. Front Matter

      Pages 80-80

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   2. Development of Tacrolimus Ointment

      • T. Goto, H. Nakagawa

      Pages 81-98

   3. Pharmacokinetics of Tacrolimus Ointment: Clinical Relevance

      • N. A. Undre

      Pages 99-110

   4. Tacrolimus as an Immunomodulator

      • T. Assmann, B. Homey, T. Ruzicka

      Pages 111-126

4. Clinical Experience with Tacrolimus Ointment in Atopic Dermatitis

   1. Front Matter

      Pages 128-128

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   2. Clinical Experience in Adults

      • S. Reitamo

      Pages 129-160

   3. Clinical Experience in Children

      • Y. de Prost

      Pages 161-183

   4. The Role of Tacrolimus Ointment in Atopic Dermatitis

      • S. Reitamo

      Pages 185-211

   5. Other Potential Dermatological Indications for Tacrolimus

      • T. Assmann, T. Ruzicka

      Pages 213-233

5. Social Impact of Atopic Dermatitis

   1. Front Matter

      Pages 235-235

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   2. Quality of Life Measurements in Atopic Dermatitis

      • A. Y. Finlay, W. H. C. Burgdorf

      Pages 237-254

   3. Pharmacoeconomics in Atopic Dermatitis

      • M. Augustin

      Pages 255-270

6. Back Matter

   Pages 271-279

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Therapeutic breakthroughs in medicine are usually accompanied by a wealth of data. Often they result in a change of disease treatment paradigms. Tacrolimus ointment is the first in the new class of steroid-free Topical Immunomodulators (TIMs), and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of T-cell mediated inflammatory skin diseases such as atopic dermatitis. This book gives an easy-to-read overview of the discovery and the development of Tacrolimus ointment for the treatment of atopic dermatitis. Summarising the largest clinical trial program ever conducted in dermatology for a new treatment with more than 13000 patients, it offers a detailed insight into the efficacy and safety profile of Tacrolimus ointment. Based on this large body of data and extensive personal experience, the authors offer practical and hands-on guidance for the physician as to when and how to use Tacrolimus ointment in daily practice.

• Dermatitis
• Dermatologie
• Neurodermitis
• dermatology
• epidemiology
• skin

• Universitätsklinikum Düsseldorf Hautklinik, Heinrich-Heine-Universität, Düsseldorf, Germany

  Thomas Ruzicka

• Hospital for Skin and Allergic Diseases, Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland

  Sakari Reitamo

Policies and ethics