Malignant Transformation by Viruses

1. Front Matter

   Pages i-xiii

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2. The Characteristics of Malignant Transformation by Viruses

   1. Malignant Transformation and Reversion in Virus Infected Cells

      • Ian Macpherson

      Pages 1-8

   2. Discussion

      • Howard Green

      Pages 9-11

   3. Malignant Conversion by Avian Sarcoma Virus

      • Howard M. Temin

      Pages 12-17

   4. Discussion

      • Warren W. Nichols

      Pages 17-19

   5. Epigenetic Factors in the Neoplastic Response to Polyoma Virus

      • Clyde J. Dawe, James H. P. Main, Marilyn S. Slatick, Willie D. Morgan

      Pages 20-33

   6. The Response of Metanephric Rudiments to Polyoma Virus in Vitro Discussion

      • W. H. Kirsten, T. P. Weis

      Pages 34-43

   7. Cell Transformation by the Mammary Tumor Virus in Vitro

      • Etienne Y. Lasfargues, Dan H. Moore

      Pages 44-55

   8. Discussion

      • K. B. DeOme

      Pages 55-59

3. Genetics and Immunology of Malignant Transformation by Viruses

   1. Specific Antigens Produced by Oncogenic Viruses

      • Karl Habel

      Pages 60-73

   2. Discussion

      • V. Defendi

      Pages 73-76

   3. Complementation Between Defective Oncogenic Viruses

      • Fred Rapp

      Pages 77-94

   4. Studies on Transformation by the Adenovirus-SV40 Hybrid Viruses

      • Paul H. Black, Howard Igel

      Pages 95-103

   5. Cytogenetic Alterations During Malignant Transformation

      • Paul S. Moorhead, David Weinstein

      Pages 104-111

   6. Relative Growth and Oncogenic Potential of Normal, Malignant, and Virus-Transformed Euploid Cells of Dwarf Species of Hamster

      • George Yerganian

      Pages 112-122

   7. Viruses and Human Neoplasm

      • Joseph L. Melnick

      Pages 123-125

4. Significance of Malignant Transformation in Relation to Human Neoplasms

   1. Transformation of Human Cells by Oncogenic Virus SV40

      • Anthony J. Girardi, Fred C. Jensen

      Pages 126-135

   2. Discussion

      • Alan S. Rabson

      Pages 135-136

   3. Immunologic Attack on Neoplasia

      • M. R. Hilleman

      Pages 137-148

   4. Round Table Discussion

      • Huebner

      Pages 149-163

The position of "Cancer Teaching Coordinator" at The University of Chicago has been a consistently rewarding one because of the enthusiasm and support of the faculty and the students. This volume is the result of the second of two recent intensive teach­ ing sessions which have been planned and implemented by the group which forms the Cancer Coordinator's Advisory Committee. The first of these teaching sessions was held in early March of 1964 and was entitled "LEUKEMIA, A Current and Forward Look. " It attracted overflow attendance from the students and staff of this medical institution augmented by members of the other medical centers in Chicago. It was a stimulating and instructive colloquium, and the only regret we heard expressed afterward was that we had not arranged for publication of the many excellent presentations. One of the events commemorating the seventy-fifth anniversary of the founding of The University of Chicago was this symposium on malignant transformations. This time the Committee advised us to plan on speedy publication, and, logically, it chose Dr. Werner Kirsten, a member of our faculty and an active and effective investigator in this general field of endeavor, to serve as editor of the volume. Again, two of the same ingredients for effective instruction were blended: an excellent group of scientists presenting their latest work and a fine, attentive audience of students and staff.

• Viruses
• cancer
• genetics
• growth
• immunology
• leukemia
• neoplasm
• tumor
• virus

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