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Isolated Liver Perfusion for Hepatic Tumors

  • Conference proceedings
  • © 1998

Overview

Editors:
  1. Karl J. Oldhafer

    1. Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany

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  2. Hauke Lang

    1. Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany

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  3. Rudolf Pichlmayr

    1. Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 147)

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Table of contents (16 papers)

  1. Front Matter

    Pages I-XI
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  3. Technique/Anaesthesia

    1. Front Matter

      Pages 17-17
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    2. Asanguineous Isolated Hyperthermic Perfusion of the Liver: Results of an Experimental Study in Pigs

      • H. Lang, S. Nadalin, L. Moreno, A. Thyen, S. R. Shehata, P. Flemming et al.
      Pages 19-27

    3. Hyperthermo-Chemo-Hypoxic Isolated Liver Perfusion for Hepatic Metastases: A Possible Adjuvant Approach

      • Y. Nakajima, M. Horikawa, T. Kin, T. Ohyama, H. Kanehiro, M. Hisanaga et al.
      Pages 28-41

    4. The Surgical Technique of Isolated Hyperthermic Arterial Liver Perfusion in Humans

      • K. J. Oldhafer, H. Lang, S. Nadalin, M. Frerker, W. Schüttler, A. Bornscheuer et al.
      Pages 42-50

    5. Monitoring Leakage During Isolated Hepatic Perfusion

      • P. Lindnér
      Pages 51-55

    6. Anesthesiological Management During Isolated Liver Perfusion

      • A. Bornscheuer, K. H. Mahr, K. Kirchhoff, K. J. Oldhafer, H. Lang, S. Piepenbrock
      Pages 56-64

  4. High-Dose Chemoperfusion

    1. Front Matter

      Pages 65-65
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    2. Percutaneous Isolated Liver Chemoperfusion for Treatment of Unresectable Malignant Liver Tumors: Technique, Pharmacokinetics, Clinical Results

      • Y. Ku, T. Iwasaki, T. Fukumoto, M. Tominaga, S. Muramatsu, N. Kusunoki et al.
      Pages 67-82

    3. Phase I/II Studies of Isolated Hepatic Perfusion with Mitomycin C or Melphalan in Patients with Colorectal Cancer Hepatic Metastases

      • A. Marinelli, A. L. Vahrmeijer, C. J. H. van de Velde
      Pages 83-94

  5. Tumor Necrosis Factor

    1. Front Matter

      Pages 95-95
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    2. Molecular Mechanisms of TNF Receptor-Mediated Signaling

      • N. P. Malek, J. Pluempe, S. Kubicka, M. P. Manns, C. Trautwein
      Pages 97-106

    3. Isolated Hepatic Perfusion with Tumor Necrosis Factor α and Melphalan: Experimental Studies in Pigs and Phase I Data from Humans

      • M. R. de Vries, I. H. Borel Rinkes, C. J. H. van de Velde, T. Wiggers, R. A. E. M. Tollenaar, P. J. K. Kuppen et al.
      Pages 107-119

    4. Isolated Hepatic Perfusion with Extracorporeal Oxygenation Using Hyperthermia TNFα and Melphalan: Swedish Experience

      • L. Hafström, P. Naredi
      Pages 120-126

  6. Radiological Control of Tumor Response

    1. Front Matter

      Pages 127-127
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    2. Role of Ultrasonography for Monitoring Tumor Necrosis After Chemotherapy

      • M. Gross, W. G. Zoller
      Pages 129-135

    3. CT and MR to Assess the Response of Liver Tumors to Hepatic Perfusion

      • M. Prokop
      Pages 136-154
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Keywords

About this book

The contributions in this book were originally presented at the workshop "Research and Clinical Application of Isolated Liver Perfusion for Hepatic Tumors" held on 28 February to 1 March 1997 in Hanover, Germany. The workshop was planned to bring together groups working with isolated liver perfusion techniques worldwide. Experts from various countries were invited to pre­ sent and discuss their experimental data and clinical results. USA par­ Groups from Japan, The Netherlands, Sweden and the ticipated. At the beginning, oncologists, surgeons and patholo­ gists presented possible indications and the oncological back­ ground for therapeutic isolated liver perfusion from their points of view. Based on data from previous studies about loco regional chemotherapy and based on the pathology of metastasis, it could be concluded that there is a place for isolated liver perfusion in the therapy of liver cancer. Second, different surgical techniques of isolated liver perfusion were presented. These techniques var­ ied from a percutaneous approach with extracorporeal chemofil­ tration to extended open abdominal surgery. Perfusion of the liv­ er without a considerable amount of drug reaching the systemic circulation proved to be possible. The complex procedure with complicated extracorporeal perfusion technique represented a disadvantage of the methods presented. Further studies should simplify the technical and surgical aspects. Intraoperative and postoperative management of . patients undergoing isolated liver perfusion were also discussed. Coagulopathy was one important aspect which can occur during isolated liver perfusion. The per­ centage of leakage determined systemic side effects.

Editors and Affiliations

  • Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany

    Karl J. Oldhafer, Hauke Lang, Rudolf Pichlmayr

Bibliographic Information

  • Book Title: Isolated Liver Perfusion for Hepatic Tumors

  • Editors: Karl J. Oldhafer, Hauke Lang, Rudolf Pichlmayr

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-80460-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin · Heidelberg 1998

  • Softcover ISBN: 978-3-642-80462-5Published: 14 December 2011

  • eBook ISBN: 978-3-642-80460-1Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XI, 191

  • Number of Illustrations: 61 b/w illustrations

  • Topics: Oncology, Imaging / Radiology

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