Role of Nitric Oxide in Sepsis and ARDS

1. Front Matter

   Pages I-XIV

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2. Biochemistry of Nitric Oxide and Regulation of Gene Expression

   1. Front Matter

      Pages 1-1

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   2. Biosynthesis of Nitric Oxide: An Overview

      • B. Mayer

      Pages 3-13

   3. Biochemistry and Synthesis of NO in Sepsis

      • L. L. Shears, T. R. Billiar

      Pages 14-28

   4. Effects of Hypoxia on Inducible Nitric Oxide Synthase (iNOS) in Renal Mesangial Cells

      • E. Michelakis, P. J. Shultz, S. L. Archer

      Pages 29-43

   5. Vascular Smooth Muscle Function under Conditions of Sepsis and Endotoxemia

      • J. R. Parratt, J. C. Stoclet

      Pages 44-61

   6. Nitric Oxide as a Mediator in Gram-Positive Sepsis

      • J. Wilkinson, S. Sriskandan, J. Cohen

      Pages 62-69

3. Effects of Nitric Oxide on Various Cell Types and Organs

   1. Front Matter

      Pages 71-71

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   2. Nitric Oxide and the Heart in Sepsis

      • A. Kumar, J. E. Parrillo

      Pages 73-99

   3. Influence of Nitric Oxide on Cardiac Systolic and Diastolic Function

      • A. M. Shah

      Pages 100-113

   4. Cellular Actions of Nitric Oxide on the Circulatory System

      • A. M. Lefer

      Pages 114-124

   5. Role of Nitric Oxide in Cerebral Ischemia

      • J. R. Kirsch, R. J. Traystman

      Pages 125-137

   6. Platelet Regulation and Damage in Vascular Thrombotic and Septic Disorders

      • M. W. Radomski, E. Salas

      Pages 138-154

   7. Nitric Oxide as a Mediator of Hypotension and Inflammation in Sepsis

      • R. L. Danner, J. Cobb, A. L. Van Dervort

      Pages 155-180

   8. Effects of Nitric Oxide on Intestinal Epithelial Structure and Function

      • M. P. Fink, N. Unno, A. L. Salzman

      Pages 181-198

4. Nitric Oxide in Shock

   1. Front Matter

      Pages 199-199

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   2. Inhibition of Nitric Oxide Synthase Activity in Circulatory Shock: Friend or Foe?

      • C. Thiemermann

      Pages 201-216

   3. Use of Nitric Oxide Synthase Inhibitors to reverse Hyperdynamic Circulation and MOF

      • M. Booke, L. D. Traber, D. L. Traber

      Pages 217-231

   4. Cardiovascular Alterations associated with Interleukin-2 Therapy

      • G. A. Fonseca, R. G. Kilbourn

      Pages 232-252

   5. Blocking the Effects of Nitric Oxide in Septic Shock

      • J. L. Vincent, J. G. Preiser, H. Zhang

      Pages 253-273

Nitric Oxide (NO) is a free radical, a gas, and a pluripotent product of mammalian cells. Only a few years ago, scientific discussions of NO were largely held in the context of the chemistry of air pollution. Now, however, the great significance of NO as a signalling and cytotoxic molecule has captured the attention of the biomedical community. This book provides a very up-to-date review of the role of NO in sepsis and ARDS. Consideration is given to NO both as a pathophysiologic mediator as well as a therapeutic agent. An internationally recognized group of scientists and clinicians have contributed chapters dealing with cutting-edge science and practical clinical strategies. Numerous tables and charts have been included to aid the reader in understanding this fascinating and important subject.

• ARDS
• Arginin
• Edotoxin
• Lipopolysaccharid
• Sepsis
• air pollution
• arginine
• attention
• cells
• cerebral ischemia
• hypoxia
• lipopolysaccharide
• molecule
• respiratory failure
• shock

• Department of Surgery, Beth Israel Hospital, Boston, USA

  M. P. Fink

• Department of Anesthesiology and Intensive Care, Lariboisière University Hospital, Paris Cedex 10, France

  Didier Payen

Policies and ethics