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Transcriptional Control of Cell Growth

The E2F Gene Family

  • Book
  • © 1996

Overview

Editors:
  1. Peggy J. Farnham

    1. McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 208)

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Table of contents (6 chapters)

  1. Front Matter

    Pages I-IX
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  2. Introduction to the E2F Family: Protein Structure and Gene Regulation

    • J. E. Slansky, P. J. Farnham
    Pages 1-30

  3. Regulatory Interactions Among E2Fs and Cell Cycle Control Proteins

    • D. Cobrinik
    Pages 31-61

  4. Use of the E2F Transcription Factor by DNA Tumor Virus Regulatory Proteins

    • W. D. Cress, J. R. Nevins
    Pages 63-78

  5. The Cellular Effects of E2F Overexpression

    • P. D. Adams, W. G. Kaelin Jr.
    Pages 79-93

  6. Start-Specific Transcription in Yeast

    • L. Breeden
    Pages 95-127

  7. Conclusions and Future Directions

    • P. J. Farnham
    Pages 129-137

  8. Back Matter

    Pages 139-144
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Keywords

About this book

It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through­ out the lifespan of all animals. An important control point in this balance occurs in the G, phase of the cell cycle. On the basis of environmental cues a cell in G, must decide whether to continue through the proliferative cycle and enter S phase (where DNA replication occurs) or to exit from the proliferative cycle into a nonreplicating state. Alterations in the mechanisms that nor­ mally control this decision can lead to cancer, cell death, or loss of differentiated cellular phenotypes. The identification of the E2F gene family of transcription factors has allowed a more complete understanding of how the cell maintains an appropri­ ate proliferative state. This volume provides an up-to-date ac­ count of present reports concerning E2F as well as a framework for future investigations. E2F activity requires heterodimerization of two partners. Either partner can be one of several different transcription factors; E2Fl, E2F2, E2F3, E2F4, or E2F5 can heterodimerize with either DPl or DP2. Cellular promoters whose E2F sites mediate a link between transcription and proliferation drive genes whose products are required for DNA synthesis and genes that encode regulators of cell growth. A detailed analY$is of the role that E2F family members play in transcription from these promoters is presented in the chapter by J. E. SLANSKY and P. J. FARNHAM.

Editors and Affiliations

  • McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, USA

    Peggy J. Farnham

Bibliographic Information

  • Book Title: Transcriptional Control of Cell Growth

  • Book Subtitle: The E2F Gene Family

  • Editors: Peggy J. Farnham

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-79910-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1996

  • Softcover ISBN: 978-3-642-79912-9Published: 14 December 2011

  • eBook ISBN: 978-3-642-79910-5Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 141

  • Number of Illustrations: 14 b/w illustrations

  • Topics: Cell Biology, Virology

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