Measles Virus

1. Front Matter

   Pages I-IX

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2. Clinical Spectrum of Measles

   • M. Katz

   Pages 1-12

3. The Epidemiology of Measles: Thirty Years of Vaccination

   • C. J. Clements, F. T. Cutts

   Pages 13-33

4. Structure, Transcription, and Replication of Measles Virus

   • S. M. Horikami, S. A. Moyer

   Pages 35-50

5. Functional Aspects of Envelope-Associated Measles Virus Proteins

   • T. F. Wild, R. Buckland

   Pages 51-64

6. Measles Virus Strain Variations

   • B. K. Rima, J. A. P. Earle, K. Baczko, P. A. Rota, W. J. Bellini

   Pages 65-83

7. Measles Virus-Mononuclear Cell Interactions

   • P. Borrow, M. B. A. Oldstone

   Pages 85-100

8. Measles Virus Gene Expression in Neural Cells

   • S. Schneider-Schaulies, J. Schneider-Schaulles, L. M. Dunster, V. Ter Meulen

   Pages 101-116

9. Immune Responses During Measles Virus Infection

   • D. E. Griffin

   Pages 117-134

10. Monkeys in Measles Research

    • R. S. Van Binnendijk, R. W. J. Van Der Heijden, A. D. M. E. Osterhaus

    Pages 135-148

11. Measles Virus Infections in Rodents

    • U. G. Liebert, D. Finke

    Pages 149-166

12. The Paradigms of Measles Vaccinology

    • E. Norrby

    Pages 167-180

13. Appendix: Measles Virus Antigenome and Protein Consensus Sequences

    • F. Radecke, M. A. Billeter

    Pages 181-192

14. Back Matter

    Pages 193-198

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Measles, also called the greatest killer of children in history, still annually affects about 50 million individuals and causes close to a million deaths primarily in developing countries. Before the advent of measles vaccine some 30 years ago, these figures were roughly three times higher. Attenuated measles virus (MV) strains, all quite closely related to the original Edmonston isolate, have a very good record as a safe and highly efficacious vaccine and have brought down the measles toll in industrialized countries to almost negligible levels. However, recent outbreaks in the USA and Europe have again brought the measles problem to public attention. Sadly enough, these outbreaks were more instrumental in inducing activities to drastically reduce and hopefully finally eradicate measles than were the ten thousand times higher number of victims in developing countries. To reach this goal, as detailed in this volume, apparently it is not enough to of the existing vaccine as was the rigorously enforce use case with smallpox eradication: the intricacies of measles disease phenomena, in particular the generalized immune suppression which favors secondary infections, require more basic knowledge of the virus-host interactions and probably the development of new vaccines for special applications such as first immunizations of very young infants in developing countries.

• Immunologie
• Impfung
• Masern
• Masernvirologie und Immunologie
• Measles
• Measles vaccination
• biology
• childhood
• diseases
• immunology
• infection
• molecular biology
• vaccination
• virology
• virus

"This volume is eminently readable with concise but state-of-the-art reports on measles research in areas of virology, molecular biology and immunology,...it will be an invaluable source of information for epidemiologists and those working in the measles vaccine research field." - British Journal of Biomedical Sciences

• Institut für Virologie und Immunbiologie der Universität Würzburg, Würzburg, Germany

  Volker Meulen

• Institut für Molekularbiologie I, Universität Zürich, Zürich, Switzerland

  Martin A. Billeter

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