Gastrointestinal Regulatory Peptides

1. Front Matter

   Pages I-XX

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2. Localization and Colocalization of Gastrointestinal Peptides

   • F. Sundler, E. Ekblad, R. Håkanson

   Pages 1-28

3. Regulation of Gastrointestinal Peptide Hormone Gene Expression

   • R. K. Pearson

   Pages 29-67

4. Post-Translational Processing of Regulatory Peptides

   • R. E. Carraway, Y. P. Loh

   Pages 69-104

5. Regulation of Peptide Secretion from Gastroenteric Endocrine Cells

   • D. L. Barber

   Pages 105-131

6. Peptide Receptors and Signal Transduction in the Digestive Tract

   • M. Laburthe, P. Kitabgi, A. Couvineau, B. Amiranoff

   Pages 133-176

7. Proteolytic Inactivation of Neurohormonal Peptides in the Gastrointestinal Tract

   • J. M. Conlon

   Pages 177-198

8. Peptidergic Regulation of Gastric Acid Secretion

   • C. S. Chew

   Pages 199-252

9. Peptides and Enteric Neural Activity

   • J. J. Galligan

   Pages 253-276

10. Peptidergic Regulation of Smooth Muscle Contractility

    • J. R. Grider

    Pages 277-295

11. Peptidergic Regulation of Intestinal Electrolyte Transport

    • S. M. O’Grady

    Pages 297-324

12. Peptidergic Regulation of Gastrointestinal Blood Flow

    • C. C. Chou, A. Alemayehu

    Pages 325-342

13. Peptidergic Regulation of Cell Proliferation Through Multiple Signaling Pathways

    • I. Zachary, E. Rozengurt

    Pages 343-362

14. Peptidergic Regulation of Mucosal Immune Function

    • Feng Chen, M. S. O’Dorisio

    Pages 363-385

15. Pathophysiological Aspects of Gut Peptide Hormones

    • R. J. Playford, J. Calam, S. R. Bloom

    Pages 387-416

16. Gastrointestinal Peptides as Therapeutic Agents and Targets: Past, Present and Future

    • T. S. Gaginella

    Pages 417-438

17. Back Matter

    Pages 439-447

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Since the discovery of the pancreatic secretagogue secretin by W. M. BAYLISS and E. H. STARLING at the inception of the twentieth century, intense interest has focused on numerous, continually expanding classes of small peptides which appear to serve as regulatory molecules in the gastrointestinal tract, brain, and other organ systems. Initially, many of these substances were, like secretin, discovered in functional assays as "factors" or "activities" extractable in minute quantities from tissues or tissue fluids. By the middle of the century, advances in biochemical and immunological methods for the purification, characterization, and quantification of biologically active peptides in organ systems, tissues, and body fluids provided further impetus to this field. It was readily appreciated that small, biologically active peptides were particularly abundant in the digestive tract. Many peptides such as vasoactive intestinal peptide, gastrin, and more recently peptide YY and galanin were in fact originally discovered in and isolated from gut tissue. Moreover, these peptides were found to have profound actions on the gastroenteropancreatic system in vivo and in vitro. During the past 2 decades, information on regulatory peptides has burgeoned as a result of technological refinements in the synthesis of peptides, improved methods for detecting and visualizing peptides and their precursors in cells and tissues from a variety of species, advances in the functional assessment of peptide activity, and the application of molecular biological techniques to the char­ acterization of peptide gene structure and expression.

• biology
• cells
• hormones
• receptor
• research
• smooth muscle
• synthesis
• hepatology

• Department of Veterinary Biology, Pharmacology Section, University of Minnesota, Saint Paul, USA

  David R. Brown

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