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Genetic Diversity of RNA Viruses

  • Book
  • © 1992

Overview

Editors:
  1. John J. Holland

    1. Department of Biology, C-016, University of California, San Diego, La Jolla, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 176)

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Table of contents (14 chapters)

  1. Front Matter

    Pages I-IX
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  2. RNA Virus Populations as Quasispecies

    • J. J. Holland, J. C. De La Torre, D. A. Steinhauer
    Pages 1-20

  3. Genetic Recombination in RNA Viruses

    • M. M. C. Lai
    Pages 21-32

  4. Foot-and-Mouth Disease Virus Populations Are Quasispecies

    • E. Domingo, C. Escarmis, M. A. Martinez, E. Martinez-Salas, M. G. Mateu
    Pages 33-47

  5. Genetic Diversity and Rapid Evolution of Poliovirus in Human Hosts

    • L. Kinnunen, T. Pöyry, T. Hovi
    Pages 49-61

  6. Mutations and A/I Hypermutations in Measles Virus Persistent Infections

    • R. Cattaneo, M. A. Billeter
    Pages 63-74

  7. Evolutionary Processes in Influenza Viruses: Divergence, Rapid Evolution, and Stasis

    • O. T. Gorman, W. J. Bean, R. G. Webster
    Pages 75-97

  8. Genetic Diversity and Slow Rates of Evolution in New World Alphaviruses

    • S. C. Weaver, R. Rico-Hesse, T. W. Scott
    Pages 99-117

  9. Emergence and Transmission of Influenza A Viruses Resistant to Amantadine and Rimantadine

    • F. G. Hayden, A. J. Hay
    Pages 119-130

  10. Selection of Zidovudine-Resistant Variants of Human Immunodeficiency Virus by Therapy

    • D. D. Richman
    Pages 131-142

  11. Genetic Diversity and Evolution of Retroviruses

    • J. M. Coffin
    Pages 143-164

  12. Retroviral Reverse Transcriptases: Error Frequencies and Mutagenesis

    • K. J. Williams, L. A. Loeb
    Pages 165-180

  13. Human Immunodeficiency Virus Type 1 Quasispecies In Vivo and Ex Vivo

    • S. Wain-Hobson
    Pages 181-193

  14. Tracing the Origin of Retroviruses

    • R. F. Doolittle, D.-F. Feng
    Pages 195-211

  15. Replication and Evolution of Viroid-Like Pathogens

    • H. D. Robertson
    Pages 213-219

  16. Back Matter

    Pages 221-228
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Keywords

About this book

Many RNA viruses have been known for decades to be genetically and biologically quite variable. Some well-known examples are influenza viruses, foot and mouth disease viruses, and Newcastle disease virus. During the past decade, it has become clear that most, it not all. , RNA viruses (riboviruses and retroviruses) are much more mutable than was recognized previously, and that this great mutability generates extremely complex populations consisting of indeterminate mixtures of related variants (Le. , "mutant swarms" or "quasispecies" populations). This is also true of DNA viruses (such as hepatitis DNA genomes via RNA transcripts B virus) which replicate their that are reverse-transcribed back to DNA. This hypermutability of RNA replicons provides great biological adaptability for RNA virus genomes. It also allows (but does not necessitate) RNA viruses, so that they can extremely rapid evolution of evolve over a million times more quickly than their eukaryotic DNA-based hosts. The genetics of RNA replicons is so unusual (and often counterintuitive) that it has many important biological conse­ quences which are neither readily apparent nor widely under­ stood. Failure to understand the distinctive aspects of RNA genetics frequently generates confusion and controversy and can adversely impact vaccine and antiviral drug programs and other applications of medical virology. The 14 chapters in this volume describe advances in a number of significant areas of RNA virus genetics and evolution.

Editors and Affiliations

  • Department of Biology, C-016, University of California, San Diego, La Jolla, USA

    John J. Holland

Bibliographic Information

  • Book Title: Genetic Diversity of RNA Viruses

  • Editors: John J. Holland

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-77011-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1992

  • Softcover ISBN: 978-3-642-77013-5Published: 08 December 2011

  • eBook ISBN: 978-3-642-77011-1Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 226

  • Topics: Virology, Medical Microbiology, Cell Biology, Allergology, Immunology

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