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The Molecular Biology of Bacterial Virus Systems

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. G. Hobom

    1. Institut für Mikrobiologie und Molekularbiologie der Universität, Giessen, Germany

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  2. R. Rott

    1. Institut für Virologie der Universität, Giessen, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 136)

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Table of contents (4 papers)

  1. Front Matter

    Pages i-vii
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  2. Retroregulation of Bacteriophage λ int Gene Expression

    • G. Guarneros
    Pages 1-19

  3. Tail Length Determination in Double-Stranded DNA Bacteriophages

    • R. W. Hendrix
    Pages 21-29

  4. Single-Stranded DNA Phage Origins

    • P. D. Baas, H. S. Jansz
    Pages 31-70

  5. Initiation of DNA Replication by Primer Proteins: Bacteriophage ø29 and Its Relatives

    • M. Salas
    Pages 71-88

  6. Back Matter

    Pages 89-90
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Keywords

About this book

The fact that none of the known DNA polymerases is able to initiate DNA chains but only to elongate from a free 3' -OH group raises the problem of how replication is initiated, both at the replication origin and on Okazaki frag­ ments. It was first shown by A. KORNBERG et al. that a general mechanism to initiate replication is through the formation of an RNA primer catalyzed by RNA polymerases or by a new class of enzymes, the primases (KORNBERG 1980). This mechanism, which can be used in the case of circular DNA molecules or linear DNAs that circularize or form concatemers, cannot be used at the ends of linear DNAs since the RNA primer is removed from the DNA chain, and there is no way of filling the gap resulting at the 5' -ends of the newly synthesized DNA chain. In some cases linear DNA molecules contain a palin­ dromic nucleotide sequence at the 3' -end that allows the formation of a hairpin structure which provides the needed free 3'-OH group for elongation. This mechanism, first proposed by CAVALIER-SMITH (1974) for eukaryotic DNA repli­ cation, was shown to take place in several systems (KORNBERG 1980, 1982). Another mechanism to initiate replication consists in the specific nicking of one of the strands of a circular double-stranded DNA, producing a 3'-OH group available for elongation (KORNBERG 1980).

Editors and Affiliations

  • Institut für Mikrobiologie und Molekularbiologie der Universität, Giessen, Germany

    G. Hobom

  • Institut für Virologie der Universität, Giessen, Germany

    R. Rott

Bibliographic Information

  • Book Title: The Molecular Biology of Bacterial Virus Systems

  • Editors: G. Hobom, R. Rott

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-73115-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1988

  • Softcover ISBN: 978-3-642-73117-4Published: 10 December 2011

  • eBook ISBN: 978-3-642-73115-0Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VII, 90

  • Topics: Medical Microbiology, Virology, Microbiology

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