Host-Parasite Cellular and Molecular Interactions in Protozoal Infections

1. Front Matter

   Pages I-XIX

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2. Trypanosoma

   1. Pattern of Variant Surface Glycoprotein Coating in Nascent Metacyclic Trypanosoma Brucei in the Salivary Glands of Glossina Morsitans

      • K. Vickerman, L. Tetley, C. M. R. Turner, J. D. Barry

      Pages 1-8

   2. Evolution of Antigenic Variation in African Trypanosomes

      • John C. Boothroyd, Thomas P. Beals

      Pages 9-18

   3. Structural Studies on the Glycophospholipid Membrane Anchor of Trypanosoma Brucei Variant Surface Glycoprotein

      • M. A. J. Ferguson, R. A. Dwek, S. W. Homans, T. W. Rademacher

      Pages 19-28

   4. Metabolism of Trypanothione and Glutathionylspermidine in Trypanosomatids

      • Alan H. Fairlamb, Graeme B. Henderson

      Pages 29-40

   5. Differentiation of Trypanosoma brucei from Bloodstream to Procyclic Trypomastigotes

      • Peter Overath, Roland Bülow, Joachim Czichos, Bernhard Ehlers

      Pages 41-49

   6. Digestive Enzymes, Receptor-Mediated Endocytosis and Their Role in the Nutrition of the Bloodstream-Form Trypanosome

      • Fred R. Opperdoes, Isabelle Coppens, Pierre Baudhuin

      Pages 51-65

   7. The Cytoskeleton of Trypanosoma Brucei: Genes and Proteins

      • R. Braun, T. Seebeck, K. Behrens, M. Imboden, A. Schneider, V. Küng

      Pages 67-72

   8. Genetic Re-Assortment of African Trypanosomes in Glossina

      • L. Jenni, R. Brun

      Pages 73-78

   9. Cell Surface Glycoproteins of Trypanosoma Cruzi

      • David Snary, Michael A. J. Ferguson, Anthony K. Allen, Michael A. Miles, Alan Sher

      Pages 79-87

   10. A Specific Inhibitor of Trypanosoma Cruzi Neuraminidase Found in Human Plasma

       • R. P. Prioli, I. Rosenberg, M. E. A. Pereira

       Pages 89-95

   11. Definition of Trypanosoma Cruzi Antigens by Antibodies and T Cells

       • L. Hudson, F. Guhl

       Pages 97-105

3. Leishmania

   1. Molecular Pathogenicity of Leishmania in Intracellular Parasitism of Macrophages: Association of Virulent Phenotype with Increased Expression of a Major Membrane Glycoprotein and Microsomal N-Acetylglucosaminyl-Transferase

      • K.-P. Chang, J. A. Kink

      Pages 107-116

   2. Infectivity of Leishmania Promastigotes is Dependent on the Expression of a 65,000 Dalton Surface Antigen

      • F. Santoro, M. Kweider, J. L. Lemesre, F. Darcy, F. S. Rizvi

      Pages 117-122

   3. Characterization of Developmentally Regulated Molecules of Leishmania

      • D. McMahon-Pratt, C. L. Jaffe, L. Kahl, P. Langer, K. Lohman, A. Pan et al.

      Pages 123-136

   4. Leishmania Antigens Probed by Monoclonal Antibodies to Leishmania Membrane and to Acetylcholine Receptor

      • K. Ph. Soteriadou, A. K. Tzinia, M. G. Hadziantoniou, S. J. Tzartos

      Pages 137-147

   5. Structural Studies on Surface Glycoproteins of Leishmania Promastigotes: Isolation, Amino Acid Composition and Amino Terminal Sequence Studies

      • Robert W. Olafson, Anne E. Wallis, Robert McMaster

      Pages 149-156

   6. Membrane Attachment of the Major Surface Protein of Leishmania Promastigotes

      • C. Bordier, R. Etges, J. Bouvier, J. Ward, M. J. Turner, M. L. Cardoso de Almeida

      Pages 157-163

   7. The Promastigote Surface Protease of Leishmania

      • Robert Etges, Jacques Bouvier, Clement Bordier

      Pages 165-168

   8. Acid Protease Activity of Leishmania gp63 and Its Possible Role in Virulence

      • Gautam Chaudhuri, K. -P. Chang

      Pages 169-173

Tropical diseases such as leishmaniasis, malaria. trypanosomiasis, toxoplasmosis and amebiasis continue to plague the world, resulting in considerable morbidity and mortality, especially in the third world countries. These diseases are caused by a group of protozoa which have, over the years, undergone evolutionary adaptation to live often intracellularly in a parasitic way of life. So well-adapted have they become that they recognize the right hosts or cells to parasitize, yet at the same time they escape recognition and destruction by the host immune system. The mechanisms of such recognition and the escape of recognition are governed largely by host-parasite surface membrane interactions at the cellular and molecular level. Unique molecules produced by unusual pathways of these parasites have also been discovered and found to play important roles in their survival in the host. Understanding these mechanisms and pathways is essential not only to formulate a rational strategy for chemo- and immuno-prophylaxis and -therapy but also to unravel the mystery of biological evolution in symbiosis and parasitism. In the advent of our knowledge on the molecular biology and biochemistry of parasite membrane and other molecules, it is opportune to examine and discuss their possible roles in host-parasite recognition and interaction in a comparative approach. To highlight the recent advances of this area in various host-parasite systems, a NATO advanced Research Workshop was held from September 27 to October 1, 1986 at Hotel Villa del Mare, Acquafredda di Maratea, Italy.

• Leishmania
• Malaria
• antibody
• biochemistry
• cell
• defense mechanism
• gene
• glycoprotein
• infection
• interferon
• parasite
• parasites
• proteins
• protozoa
• toxoplasma gondii

• Department of Microbiology and Immunology, UHS/Chicago Medical School, North Chicago, USA

  K.-P. Chang

• Department of Molecular Biology, Wellcome Research Laboratories, Beckenham, Kent, England

  David Snary

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