Systemic Lupus Erythematosus

1. Front Matter

   Pages I-XIV

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2. General Considerations

   1. Front Matter

      Pages 1-1

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   2. Description of Systemic Lupus Erythematosus: A Historical Perspective

      • W. Graninger, J. S. Smolen, C. C. Zielinski

      Pages 2-5

   3. Etiologic and Pathogenetic Aspects of Systemic Lupus Erythematosus: A Critical Approach

      • W. Graninger, C. C. Zielinski, J. S. Smolen

      Pages 6-20

3. Animal Models of Systemic Lupus Erythematosus: Genetic, Viral and Immunologic Aspects

   1. Front Matter

      Pages 21-21

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   2. Genetic Aspects of Murine Lupus

      • M. F. Seldin, J. D. Mountz, A. D. Steinberg

      Pages 22-49

   3. Autoimmune Disease in New Zealand Mice

      • T. M. Chused, K. L. McCoy, R. B. Lal, Th. R. Malek, E. M. Brown, L. J. Edison et al.

      Pages 50-59

   4. The NZB × SWR Model: Insights into Viral, Immunologic, and Genetic Factors

      • S. K. Datta

      Pages 60-72

   5. Relevance of the Murine Models of Systemic Lupus Erythematosus to Human Disease

      • C. A. Laskin, H. R. Smith

      Pages 73-85

4. Immunologic and Genetic Aspects of Human SLE

   1. Front Matter

      Pages 87-87

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   2. The Importance of the Study of Monoclonal Antibodies

      • D. Isenberg, Y. Shoenfeld, R. S. Schwartz

      Pages 88-104

   3. ANA Subsets in Systemic Lupus Erythematosus

      • M. Reichlin, J. B. Harley

      Pages 105-123

   4. Complement and Complement Deficiencies

      • G. Tappeiner

      Pages 124-144

   5. The Role of Lymphokines in the Pathogenesis of Systemic Lupus Erythematosus

      • T. A. Luger, J. S. Smolen

      Pages 145-167

5. Clinical Aspects of Human SLE

   1. Front Matter

      Pages 169-169

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   2. Clinical and Serologic Features: Incidence and Diagnostic Approach

      • J. S. Smolen

      Pages 170-196

   3. Immunologic Similarities and Differences Between Systemic Lupus Erythematosus and Sjögren’s Syndrome

      • H. M. Moutsopoulos

      Pages 197-203

   4. Pathology

      • W. Ulrich, G. Syré

      Pages 204-226

   5. Cutaneous Manifestations

      • T. A. Luger, D. Benesch

      Pages 227-250

   6. Neurological Manifestations

      • E. Maida, E. Horvatits

      Pages 251-269

More than 140 years ago, lupus erythematosus (LE) was recognized as a disease entity by clinicians working in the field of dermatology, which had only recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has attracted renewed attention re­ cently and who succeeded FERDINAND VON HEBRA to the chair of dermatology at the Medical Faculty in Vienna. The early description of lupus erythematosus in both its cutaneous and systemic manifes­ tations was thus intimately associated with Vienna and its Medical School. The next phase in the study of lupus was characterized by an in­ crease in knowledge of the type and extent of organ involvement. The work by OSLER [2], LIBMANN and SACKS [3], and KLEMPERER [4] best represents these advances. The increase in clinical knowledge of LE finally led to DUBOIS' famous monograph [5], which was pub­ lished at a time of renewed interest in SLE, elicited by the descrip­ tion by HARGRAVES et al. [6] of the LE-cell phenomenon. A more detailed analysis of this finding revealed that the disease was charac­ terized by an abnormal immune response, although its pathogenetic implications were still unclear.

• antibody
• attention
• autoimmune disease
• autoimmunity
• dermatology
• immune response
• immunity
• organ
• pathogenesis
• pathology
• skin
• systemic lupus erythematosus

• Allgemeines Krankenhaus der Stadt Wien, II. Medizinische Universitätsklinik, Wien, Austria

  Josef S. Smolen, Christoph C. Zielinski

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