Caffeine

1. Front Matter

   Pages I-XX

   PDF

2. Metabolism and Kinetics

   1. Front Matter

      Pages 1-1

      PDF

   2. Products of Metabolism of Caffeine

      • M. J. Arnaud

      Pages 3-38

   3. Measurement of Caffeine and Its Metabolites in Biological Fluids

      • H. D. Christensen, A. H. Neims

      Pages 39-47

   4. Interspecies Comparison of Caffeine Disposition

      • M. Bonati, S. Garattini

      Pages 48-56

3. Intake

   1. Front Matter

      Pages 57-57

      PDF

   2. Human Consumption of Caffeine

      • J. J. Barone, H. Roberts

      Pages 59-73

4. Physiological and Behavioral Effects

   1. Front Matter

      Pages 75-75

      PDF

   2. The Cardiovascular Effects of Caffeine

      • D. Robertson, P. W. Curatolo

      Pages 77-85

   3. Behavioral Effects of Caffeine

      • P. B. Dews

      Pages 86-103

5. Mechanisms of Effects

   1. Front Matter

      Pages 105-105

      PDF

   2. Effects of Caffeine on Monoamine Neurotransmitters in the Central and Peripheral Nervous System

      • J. D. Fernstrom, M. H. Fernstrom

      Pages 107-118

   3. Neuroendocrine Effects of Caffeine in Rat and Man

      • E. R. Spindel, R. J. Wurtman

      Pages 119-128

   4. Adenosine as a Mediator of the Behavioral Effects of Xanthines

      • S. H. Snyder

      Pages 129-141

   5. Caffeine and the Cardiovascular Effects of Physiological Levels of Adenosine

      • W. R. von Borstel, R. J. Wurtman

      Pages 142-150

6. Direct Assessments of Effects on Health

   1. Front Matter

      Pages 151-151

      PDF

   2. Influence of Ingested Caffeine on Animal Reproduction

      • W. R. Gomes

      Pages 153-164

   3. The Teratogenic Potential of Caffeine in Laboratory Animals

      • J. G. Wilson, W. J. Scott Jr.

      Pages 165-187

   4. Epidemiologic Studies of Birth Defects

      • A. Leviton

      Pages 188-200

   5. The Carcinogenic Potential of Caffeine

      • H. C. Grice

      Pages 201-220

Before the late 1970s, interest in caffeine among both the general public and the scientific community was at a relatively low level for many years, even though it was recognized that caffeine was an al­ most universal component of the diet. The National Coffee Associa­ tion was supporting a continuing program of research, some re­ search was being conducted by a few of the largest companies selling coffee, and an occasional university researcher became inter­ ested in caffeine and conducted experiments, often on effects of caf­ feine in very high concentration in vitro on skeletal muscle fibres or on dividing cells. Since 1978, however, there has been a mighty up­ surge in both public and scientific interest in caffeine. It is interest­ ing to note that this was prompted not by discovery of hitherto un­ known effects or hazards of caffeine, but by the actions of a regulatory agency, the Food & Drug Administration (FDA) of the U. S. Public Health Service. The U. S. Congress passed new laws on foods and drugs in 1958. One of the provisions was for testing of food additives to assess risk to health. As it was clearly impracticable to require immediate test­ ing of all additives already in use, a list was drawn up of some hun­ dreds of additives that were generally recognized as safe (GRAS).

• Coffein
• Serotonin
• Xanthin
• absorption
• biology
• cancer
• chromatography
• drug
• kinetics
• metabolism
• neurotransmitter
• pharmacology
• research
• toxicity
• treatment

• Newtonville, USA

  P. B. Dews

Policies and ethics