The Molecular Biology of Adenoviruses I

1. Front Matter

   Pages I-XII

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2. Structure and Assembly of Adenoviruses

   • Lennart Philipson

   Pages 1-52

3. The Mechanism of Adenovirus DNA Replication and the Characterization of Replication Proteins

   • John S. Sussenbach, Peter C. van der Vliet

   Pages 53-73

4. The Origin of Adenovirus DNA Replication

   • Fuyuhiko Tamanoi, Bruce W. Stillman

   Pages 75-87

5. A New Mechanism for the Initiation of Replication of Φ29 and Adenovirus DNA:Priming by the Terminal Protein

   • Margarita Salas

   Pages 89-106

6. The Messenger RNAs from the Transforming Region of Human Adenoviruses

   • Ulf Pettersson, Anders Virtanen, Michel Perricaudet, Göran Akusjärvi

   Pages 107-123

7. In Vitro Transcription of Adenovirus Genes

   • Roberto Weinmann, Steven Ackerman, David Bunick, Michael Concino, Ruben Zandomeni

   Pages 125-145

8. Adenovirus Early Gene Regulation and the Adeno–associated Virus Helper Effect

   • William D. Richardson, Heiner Westphal

   Pages 147-165

9. Antibodies to Synthetic Peptides Targeted to the Transforming Genes of Human Adenoviruses: An Approach to Understanding Early Viral Gene Function

   • Maurice Green, Karl H. Brackmann, Lynne A. Lucher, Janey S. Symington

   Pages 167-192

10. On the Mechanism of Recombination Between Adenoviral and Cellular DNAs: The Structure of Junction Sites

    • W. Doerfler, R. Gahlmann, S. Stabel, R. Deuring, U. Lichtenberg, M. Schulz et al.

    Pages 193-228

11. Back Matter

    Pages 229-234

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A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de­ velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo­ lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu­ dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans­ formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea­ lized in the late 1960s and the 1970s.

• DNA
• biology
• cell
• genetics
• molecular biology
• virology
• virus

• Institut für Genetik, Universität zu Köln, Köln 41, Germany

  Walter Doerfler

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