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Snake Venoms

  • Book
  • © 1979

Overview

Editors:
  1. Chen-Yuan Lee

    1. College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 52)

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Table of contents (28 chapters)

  1. Front Matter

    Pages I-XXXIII
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  2. History, Ecological and Zoological Aspects

    1. Front Matter

      Pages 1-1
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    2. History of Snake Venom Research

      • P. Boquet
      Pages 3-14

    3. Classification and Distribution of Venomous Snakes in the World

      • G. Underwood
      Pages 15-40

    4. The Venom Glands of Snakes and Venom Secretion

      • A. Bdolah
      Pages 41-57

  3. Chemistry and Biochemistry of Snake Venoms

    1. Front Matter

      Pages 59-59
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    2. Enzymes in Snake Venom

      • S. Iwanaga, T. Suzuki
      Pages 61-158

    3. Chemistry of Protein Toxins in Snake Venoms

      • E. Karlsson
      Pages 159-212

    4. The Three-Dimensional Structure of Postsynaptic Snake Neurotoxins: Consideration of Structure and Function

      • Barbara W. Low
      Pages 213-257

    5. The Evolution of Toxins Found in Snake Venoms

      • D. J. Strydom
      Pages 258-275

    6. Nerve Growth Factors in Snake Venoms

      • R. A. Hogue-Angeletti, R. A. Bradshaw
      Pages 276-294

    7. Metal and Nonprotein Constituents in Snake Venoms

      • A. L. Bieber
      Pages 295-306

  4. Pharmacology of Snake Venoms

    1. Front Matter

      Pages 307-307
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    2. The Action of Snake Venoms on Nerve and Muscle

      • C. C. Chang
      Pages 309-376

    3. The Use of Snake Toxins for the Study of the Acetylcholine Receptor and its Ion-Conductance Modulator

      • E. X. Albuquerque, A. T. Eldefrawi, M. E. Eldefrawi
      Pages 377-402

    4. Pharmacology of Phospholipase A2 from Snake Venoms

      • P. Rosenberg
      Pages 403-447

    5. Hemolytic Effects of Snake Venoms

      • E. Condrea
      Pages 448-479

    6. Hemorrhagic, Necrotizing and Edema-Forming Effects of Snake Venoms

      • A. Ohsaka
      Pages 480-546

    7. Cardiovascular Effects of Snake Venoms

      • C. Y. Lee, S. Y. Lee
      Pages 547-590

    8. Liberation of Pharmacologically Active Substances by Snake Venoms

      • A. M. Rothschild, Z. Rothschild
      Pages 591-628
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Keywords

About this book

The past decade has been a period of explosion of knowledge on the chemistry and pharmacology of snake toxins. Thanks to the development of protein chemistry, nearly a hundred snake toxins have been purified and sequenced, representing one of the largest families of sequenced proteins. Moreover, the mode of action of these toxins has been largely elucidated by the concerted efforts of pharmacologists, electro physiologists, and biochemists. As a result of these studies, some of the snake toxins, e.g., a-bungarotoxin and cobra neurotoxins, have been extensively used as specific markers in the study of the acetylcholine receptors. Indeed, without the discovery of these snake toxins, our knowledge of the structure and function of nicotinic acetylcholine receptors would not have advanced so rapidly. The contribution of snake venom research to the biomedical sciences is not limited to the study of cholinergic receptors. Being one of the most concentrated enzyme sources in nature, snake venoms are also valuable tools in biochemical research. Venom phosphodiesterase, for example, has been widely used for structural studies of nucleic acids; proteinase, for the sequence studies of proteins and pep tides ; phospholipase A , for lipid research; and L-amino acid oxidase for identifying optical z isomers of amino acids. Furthermore, snake venoms have proven to be useful agents for clarifying some basic concepts on blood coagulation and some venom enzymes, e.g., thrombin-like enzymes and pro coagulants have been used as therapeutic agents.

Editors and Affiliations

  • College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

    Chen-Yuan Lee

Bibliographic Information

  • Book Title: Snake Venoms

  • Editors: Chen-Yuan Lee

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-66913-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1979

  • Softcover ISBN: 978-3-642-66915-6Published: 15 November 2011

  • eBook ISBN: 978-3-642-66913-2Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXXIV, 1132

  • Topics: Medicine/Public Health, general

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