Hypolipidemic Agents

1. Front Matter

   Pages I-XV

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2. Cholesterol Biosynthesis in vitro

   • Mary E. Dempsey

   Pages 1-28

3. Cholesterol Metabolism in Man

   • H. S. Sodhi

   Pages 29-107

4. Bile Acid Metabolism

   • T. A. Miettinen

   Pages 109-150

5. Mechanisms of Hyperlipidemia

   • J. M. Felts, L. L. Rudel

   Pages 151-189

6. Lipoproteins and Lipoprotein Metabolism

   • S. Eisenberg, R. I. Levy

   Pages 191-213

7. Animal Models for Atherosclerosis Research

   • D. Kritchevsky

   Pages 215-227

8. Lipoprotein Formation in the Liver Cell Ultrastructural and Functional Aspects Relevant to Hypolipidemic Action

   • W. Stäubli, R. Hess

   Pages 229-289

9. Vascular Metabolism, Vascular Enzymes, and the Effect of Drugs

   • T. Zemplényi

   Pages 291-348

10. Hypolipidemic Agents

    • W. L. Bencze

    Pages 349-408

11. The Rationale for Hypolipemic Therapy

    • I. D. Frantz

    Pages 409-415

12. Back Matter

    Pages 417-490

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The major cause of death in the Western world is some form of vascular disease; and principal among these forms is atherosclerotic heart disease (ASHD). Although much is known about the etiology and treatment of ASHD, there is, as yet, no specific means of prognosis of an impending coronary episode. There are, however, several indications of susceptibility to coronary disease, generally known as risk factors, the foremost of which is hyperlipidemia. Hyperlipidemia is more commonly designated as hypercholesteremia or triglyceridemia, depending upon which moiety is elevated, but since lipids are transported in the blood as members of a lipoprotein complex, the most descriptive general term would be hyperlipoproteinemia. This volume represents an effort to elucidate the origins and metabolic behavior of lipoproteins and their components, to describe aspects of the morphology, biochemistry and experimental induction of ASHD, and to describe modalities of treatment. The contributions to this book include descriptions of cholesterol synthesis and metabolism, as well as the metabolism of bile acids, the principal products of cholesterol metabolism. There are also chapters on the mechanisms of hyperlipidemia and on lipoprotein metabolism. The induction of experimental atherosclerosis and the aortic structural changes caused by this disease are discussed.

• Arterienverkalkung
• Cholesterin
• Gallensäure
• Hyperlipoproteinämie
• Lipoprotein
• agents
• biochemistry
• chemistry
• heart
• lipide
• metabolism
• research

• The Wistar Institute of Anatomy and Biology, Philadelphia, USA

  David Kritchevsky

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