Skip to main content
SpringerLink
Log in
Book cover

Viral Proteins Counteracting Host Defenses

  • Book
  • © 2002

Overview

Editors:
  1. Ulrich H. Koszinowski

    1. Max von Pettenkofer Institute, University of Munich, Munich, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Hartmut Hengel

    1. Robert Koch-Institut, Fachgebiet 1.2 Virale Infektionen, Berlin, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 269)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (16 chapters)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Strategies for the Identification and Analysis of Viral Immune-Evasive Genes — Cytomegalovirus as an Example

    • A. Gutermann, A. Bubeck, M. Wagner, U. Reusch, C. Ménard, U. H. Koszinowski
    Pages 1-22

  3. Avoiding Proteasomal Processing: The Case of EBNA1

    • N. P. Dantuma, A. Sharipo, M. G. Masucci
    Pages 23-36

  4. The HCMV Gene Products US2 and US11 Target MHC Class I Molecules for Degradation in the Cytosol

    • F. J. van der Wal, M. Kikkert, E. Wiertz
    Pages 37-55

  5. Corking the Bottleneck: The Transporter Associated with Antigen Processing as a Target for Immune Subversion by Viruses

    • F. Momburg, H. Hengel
    Pages 57-74

  6. Herpes Viral Proteins Manipulating the Peptide Transporter TAP

    • E. Reits, A. Griekspoor, J. Neefjes
    Pages 75-83

  7. Herpes Viral Proteins Blocking the Transporter Associated with Antigen Processing TAP — From Genes to Function and Structure

    • D. Bauer, R. Tampé
    Pages 85-99

  8. Inhibition of the MHC Class II Antigen Presentation Pathway by Human Cytomegalovirus

    • D. C. Johnson, N. R. Hegde
    Pages 101-115

  9. Viral Evasion of Natural Killer Cells During Human Cytomegalovirus Infection

    • V. M. Braud, P. Tomasec, G. W. G. Wilkinson
    Pages 117-129

  10. Function of CMV-Encoded MHC Class I Homologues

    • H. E. Farrell, N. J. Davis-Poynter, D. M. Andrews, M. A. Degli-Esposti
    Pages 131-151

  11. Human Cytomegalovirus Inhibition of Major Histocompatibility Complex Transcription and Interferon Signal Transduction

    • D. M. Miller, C. M. Cebulla, D. D. Sedmak
    Pages 153-170

  12. Counteraction of Interferon-Induced Antiviral Responses by Herpes Simplex Viruses

    • D. A. Leib
    Pages 171-185

  13. Immune Evasion Strategies of Kaposi’s Sarcoma-Associated Herpesvirus

    • R. E. Means, J. K. Choi, H. Nakamura, Y. H. Chung, S. Ishido, J. U. Jung
    Pages 187-201

  14. Viral Chemokine Receptors and Chemokines in Human Cytomegalovirus Trafficking and Interaction with the Immune System

    • P. S. Beisser, C.-S. Goh, F. E. Cohen, S. Michelson
    Pages 203-234

  15. Fatal Attraction: Cytomegalovirus-Encoded Chemokine Homologs

    • N. Saederup, E. S. Mocarski Jr
    Pages 235-256

  16. Herpesviral Proteins Regulating Apoptosis

    • T. Derfuss, E. Meinl
    Pages 257-272

  17. Subversion of Host Defense Mechanisms by Adenoviruses

    • H.-G. Burgert, Z. Ruzsics, S. Obermeier, A. Hilgendorf, M. Windheim, A. Elsing
    Pages 273-318

  18. Back Matter

    Pages 319-328
    Download chapter PDF
Back to top

Keywords

About this book

Since the first observations of viral interference with antigen presentation in the MHC class-I pathway, the field has advanced to a detailed analysis. We know numerous genes and for some of them we have profound information on their mechanistic function. The antigen presentation pathway is affected at all stages starting from proteasomal degradation of an antigenic viral protein, as shown for EBV, transfer of the proteasomal cleavage products as peptides in the ER by specific transporters, the loading of the nascent MHC class-I molecule, and finally the transport of the complex to the surface and presentation in a normal or deranged form. All these different steps of the MHC class-I antigen presentation pathway are targets for viral proteins. Not only MHC class-I but also MHC class-II proteins are a target of viral influence either by direct downregulation and degradation of proteins or by interference of signal transduction pathways.

Editors and Affiliations

  • Max von Pettenkofer Institute, University of Munich, Munich, Germany

    Ulrich H. Koszinowski

  • Robert Koch-Institut, Fachgebiet 1.2 Virale Infektionen, Berlin, Germany

    Hartmut Hengel

Bibliographic Information

  • Book Title: Viral Proteins Counteracting Host Defenses

  • Editors: Ulrich H. Koszinowski, Hartmut Hengel

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-59421-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2002

  • Softcover ISBN: 978-3-642-63974-6Published: 14 October 2011

  • eBook ISBN: 978-3-642-59421-2Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XI, 325

  • Number of Illustrations: 4 illustrations in colour

  • Topics: Virology, Immunology

Publish with us

Policies and ethics

Back to top

Search

Navigation