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Nitric Oxide

  • Book
  • © 2000

Overview

Editors:
  1. Bernd Mayer

    1. Department of Pharmacology and Toxicology, Karl-Franzens-University of Graz, Graz, Austria

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 143)

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Table of contents (25 chapters)

  1. Front Matter

    Pages I-XXIX
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  2. Introduction

    1. Introduction

      • S. Moncada
      Pages 1-3

  3. Chemistry

    1. Front Matter

      Pages 5-5
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    2. The Chemical Biology of Nitric Oxide. Balancing Nitric Oxide with Oxidative and Nitrosative Stress

      • D. A. Wink, K. M. Miranda, M. G. Espey, J. B. Mitchell, M. B. Grisham, J. Fukuto et al.
      Pages 7-29

  4. Biochemistry and Pharmacology of NO Synthesis and Action

    1. Front Matter

      Pages 31-31
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    2. Enzymology of Nitric Oxide Synthases

      • D. J. Stuehr, S. Ghosh
      Pages 33-70

    3. Regulation of Nitric Oxide Synthase Expression and Activity

      • U. Förstermann
      Pages 71-91

    4. Enzymology of Soluble Guanylyl Cyclase

      • D. Koesling, A. Friebe
      Pages 93-109

    5. Nitric Oxide Synthase Inhibitors I: Substrate Analogs and Heme Ligands

      • J. F. Parkinson
      Pages 111-135

    6. Nitric-Oxide-Synthase Inhibitors II — Pterin Antagonists/Anti-Pterins

      • E. R. Werner, H. H. H. W. Schmidt
      Pages 137-158

    7. Mechanisms of Cellular Resistance Against Nitric Oxide

      • B. BrüNe, A. Von Knethen, K. Sandau
      Pages 159-175

  5. Physiological Functions of NO

    1. Front Matter

      Pages 177-177
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    2. Nitric Oxide and Regulation of Vascular Tone

      • R. Busse, I. Fleming
      Pages 179-206

    3. Regulation of Cardiac Function by Nitric Oxide

      • J.-L. Balligand
      Pages 207-234

    4. Regulation of Platelet Function

      • L. McNaughton, A. Radomski, G. Sawicki, Marek W. Radomski
      Pages 235-257

    5. The Physiological Roles of Nitric Oxide in the Central Nervous System

      • J. Garthwaite
      Pages 259-275

    6. The Role of Nitric Oxide in the Peripheral Nervous System

      • W. Martin
      Pages 277-313

    7. Nitric Oxide and Neuroendocrine Function

      • P. Navarra, A. Costa, A. Grossman
      Pages 315-328

    8. The Role of Nitric Oxide in Kidney Function

      • E. Hackenthal
      Pages 329-361

  6. The Role of Pharmacological Action of NO in Human Disease

    1. Front Matter

      Pages 363-363
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Keywords

About this book

Nitric oxide (NO) has been discovered to play a fundamental role in a number of biological phenomena. This book describes various aspects of nitric oxide biology, physiology and pharmacology. It is divided into three sections. The first part deals with the basic chemistry and enzymology of NO, thus laying a molecular basis for what follows. The middle part surveys the physiological roles of NO under normal conditions. The concluding part explores the relevance of NO to disease, both as a pathogenic factor and a therapeutic target. The book thus provides detailed information on NO biology to the reader unfamiliar with the field and represents a reference work for scientists working in an NO-related field of biomedical research. Each chapter, written by experts in their fields, gives a broad introduction followed by a comprehensive review of the current knowledge and a detailed reference list.

Editors and Affiliations

  • Department of Pharmacology and Toxicology, Karl-Franzens-University of Graz, Graz, Austria

    Bernd Mayer

Bibliographic Information

  • Book Title: Nitric Oxide

  • Editors: Bernd Mayer

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-57077-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Hardcover ISBN: 978-3-540-66122-1Published: 26 April 2000

  • Softcover ISBN: 978-3-642-63026-2Published: 11 October 2012

  • eBook ISBN: 978-3-642-57077-3Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXIX, 667

  • Number of Illustrations: 74 b/w illustrations

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Molecular Medicine

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