Estrogens and Antiestrogens II

1. Front Matter

   Pages I-XXXIII

   PDF

2. Part 5: Pharmacology of Estrogens and Antiestrogens

   1. Front Matter

      Pages 1-1

      PDF

   2. In Vitro and In Vivo Models to Characterise Estrogens and Antiestrogens

      • K.-H. Fritzemeier, C. Hegele-Hartung

      Pages 3-94

   3. Estrogen Receptor β in the Pharmacology of Estrogens and Antiestrogens

      • G. Kuiper, M. Warner, J.-Å Gustafsson

      Pages 95-104

   4. Interrelationship of Estrogens with other Hormones or Endocrine Systems

      • N. Navizadeh, F.Z. Stanczvk

      Pages 105-111

   5. Mammary Gland

      • G. Söderqvist, B. Von Schoultz

      Pages 113-128

   6. Cardiovascular System

      • G. Samsioe

      Pages 129-140

   7. Bone

      • B. Winding, H. JØrgensen, C. Christiansen

      Pages 141-149

   8. Central Nervous System

      • R. Gallo, M. Stomati, A. Spinetti, F. Petraglia, A. R. Genazzani

      Pages 151-162

   9. Liver Inclusive Protein, Lipid and Carbohydrate Metabolism

      • L. Sahlin, B. von Schoultz

      Pages 163-178

   10. Pharmacology of Antiestrogens

       • A. E. Wakeling

       Pages 179-194

   11. Oncology

       • E. V. Jensen

       Pages 195-203

   12. Hormonal Resistance in Breast Cancer

       • S. R. D. Johnston, E. Anderson, M. Dowsett, A. Howell

       Pages 205-221

   13. Pharmacology of Inhibitors of Estrogen Biosynthesis

       • A. S. Bhatnagar, W. R. Miller

       Pages 223-230

   14. Pharmacology of Inhibition of Estrogen-Metabolizing Enzymes

       • M. J. Reed, A. Purohit

       Pages 231-245

   15. Pharmacology of Different Administration Routes - Oral vs Transdermal

       • R. Sitruk-Ware

       Pages 247-257

3. Part 6: Kinetics and Toxicology of Estrogens and Antiestrogens

   1. Front Matter

      Pages 259-259

      PDF

   2. Pharmacokinetics of Exogenous Natural and Synthetic Estrogens and Antiestrogens

      • W. Kuhnz, H. Blode, H. Zimmermann

      Pages 261-322

   3. Toxicology of Estrogens and Antiestrogens

      • H. Zimmermann

      Pages 323-351

   4. Estrogens and Sexually Transmitted Diseases

      • M. Dören

      Pages 353-360

For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and anti estrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of pUblications from which new principles of preventive and therapeutic appli­ cations of estrogens and anti estrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro­ gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu­ ously hallmark results in reproductive endocrinology worldwide.

• Estrogens
• Hydra
• Lipid
• Vivo
• antiestrogens
• enzymes
• influence
• metabolism
• pathophysiology
• physiology

• Jenapharm GmbH & Co. KG, Jena, Germany

  Michel Oettel

• Schering Aktiengesellschaft, Germany

  Ekkehard Schillinger

Policies and ethics