Drosophila Eye Development

1. Front Matter

   Pages I-XI

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2. Introduction

   • Kevin Moses

   Pages 1-3

3. Retinal Specification and Determination in Drosophila

   • Kartik Pappu, Graeme Mardon

   Pages 5-20

4. Regulators of the Morphogenetic Furrow

   • Jeffrey D. Lee, Jessica E. Treisman

   Pages 21-33

5. NOTCH and the Patterning of Ommatidial Founder Cells in the Developing Drosophila Eye

   • Nicholas E. Baker

   Pages 35-58

6. The Epidermal Growth Factor Receptor in Drosophila Eye Development

   • Justin P. Kumar

   Pages 59-71

7. Cell Fate Specification in the Drosophila Eye

   • Raghavendra Nagaraj, Jude Canon, Utpal Banerjee

   Pages 73-88

8. Tissue Polarity in the Retina

   • Marek Mlodzik

   Pages 89-106

9. Regulation of Growth and Cell Proliferation During Eye Development

   • Thomas P. Neufeld, Iswar K. Hariharan

   Pages 107-133

10. Evolution of Color Vision

    • Franck Pichaud, Claude Desplan

    Pages 135-149

11. Developmental Regulation Through Protein Stability

    • Janice A. Fischer

    Pages 151-167

12. Programmed Death in Eye Development

    • Rebecca Hays, Caroline Craig, Ross Cagan

    Pages 169-189

13. Drosophila Compound Eye Morphogenesis: Blind Mechanical Engineers?

    • Donald F. Ready

    Pages 191-204

14. The Establishment of Retinal Connectivity

    • Ulrike Gaul

    Pages 205-218

15. Homologies Between Vertebrate and Invertebrate Eyes

    • Volker Hartenstein, Thomas A. Reh

    Pages 219-255

16. Applications of the Drosophila Retina to Human Disease Modeling

    • Nancy M. Bonini, Mark E. Fortini

    Pages 257-275

17. Back Matter

    Pages 277-282

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1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.

• Activation
• DNA
• Drosophila
• Eye
• Genetics
• Genetik
• Invertebrate
• Signalübertragung
• Termination
• Vertebrate
• conservation
• genes
• growth cones
• regulation
• signal transduction

• Department of Cell Biology, Emory University School of Medicine, Atlanta, USA

  Kevin Moses

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