Late Sequelae in Oncology

1. Front Matter

   Pages I-XI

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2. Individual Variation of Radio- and Chemosensitivity

   1. Front Matter

      Pages 1-1

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   2. Impact of Endogenous and Exogenous Factors on Radiation Sequelae

      • Michael Baumann

      Pages 3-12

   3. Endogenous and Exogenous Factors Modifying Chemosensitivity to Cytostatic Drugs

      • Hans-Jörg Sauer

      Pages 13-19

3. Neurotoxicity

   1. Front Matter

      Pages 21-21

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   2. Radiation-Induced Injury of the Central Nervous System

      • Rolf-Peter Müller

      Pages 23-27

   3. Cytostatic-Induced Central Nervous System Abnormalities

      • Rudolf Korinthenberg

      Pages 29-34

   4. Radiation Myelopathy

      • Ludwig Keilholz, Jürgen Dunst

      Pages 35-42

   5. Acute and Late Toxicity on Peripheral Nerves After Radiotherapy

      • Clemens F. Hess, Rolf D. Kortmann, Michael Bamberg, Martin Schabet

      Pages 43-49

   6. Acute and Late Toxicity on Peripheral Nerves After Chemotherapy — A Review

      • Carsten Bokemeyer, H.-J. Schmoll, Bernd Frank

      Pages 51-58

   7. Endocrine Dysfunction After Brain Tumor Therapy in Children

      • Helmuth G. Dörr, Andreas Koch, Thorsten Sauerwald, Jörn D. Beck

      Pages 59-64

   8. Endocrine Dysfunction in Adults After Radiotherapy for Pituitary Adenomas and Suprasellar Tumors

      • Michael Buchfelder, Gerhard Grabenbauer

      Pages 65-71

   9. Late Sequelae Affecting the Ear

      • Stefan Birkenhake

      Pages 73-79

   10. Ototoxicity in Pediatric Oncology

       • Sabine Hartmann

       Pages 81-86

4. Skin and Mucosal Toxicity

   1. Front Matter

      Pages 87-87

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   2. Biological Basis for Skin and Mucosal Toxicity

      • Klaus-Rüdiger Trott

      Pages 89-91

   3. Radiation-Induced Fibrosis: Experimental Studies

      • H. Peter Rodemann, Anke Binder, Michael Bamberg

      Pages 93-97

   4. Lymphedema of the Arm After Treatment of Breast Cancer

      • Heinrich Schünemann, Norman Willich

      Pages 99-104

   5. Skin and Mucosal Damage After Radiotherapy for Head and Neck Tumors

      • Marcus Niewald, Klaus Schnabel, Werner Berberich, Michael Engel, Armand Koch

      Pages 105-110

   6. Mucosal Toxicity After Radiochemotherapy

      • Ludwig Plasswilm, Vratislav Strnad

      Pages 111-119

Increasing survival figures and the use of more intense combined treatment regimens in modern oncology have raised the problem of late therapeutic sequelae in long-term survivors after cancer. Recent scientific approaches to late sequelae concentrate on the evaluation of subclinical changes with sophisticated functional measurements and experimental investigation of the underlying pathophysiological mechanisms.
The objective of the book is to bring together these recent clinical and experimental data from different medical disciplines to give an overview of the most relevant problems of late sequelae. In clinical practice the book may help regarding estimation of risks, selection of diagnostic methods, and estimation of the prognosis of late sequelae.

• Chemotherapie
• Krebsbehandlung
• Oncology
• Onkologie
• Radiotherapie
• Spätfolgen
• cancer
• cancer treatment
• chemotherapy
• late sequelae
• radiotherapy
• Radiaton Oncology

• Strahlentherapeutische Klinik, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany

  Jürgen Dunst

• Klinik und Poliklinik für Strahlentherapie, Universität Erlangen-Nürnberg, Erlangen, Germany

  Rolf Sauer

Policies and ethics