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Thymic Development and Selection of T Lymphocytes

  • Book
  • © 2014

Overview

Editors:
  1. Thomas Boehm

    1. Department of Developmental Immunology, Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany

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  2. Yousuke Takahama

    1. Institute for Genome Research, Division of Experimental Immunology, University of Tokushima, Tokushima, Japan

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  • Written by leading experts in the field
  • Addresses key aspects of the process of thymopoiesis
  • Offers perspectives for understanding immunodeficiency and autoimmune diseases
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 373)

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-vii
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  2. Development and Function of Cortical Thymic Epithelial Cells

    • Kensuke Takada, Izumi Ohigashi, Michiyuki Kasai, Hiroshi Nakase, Yousuke Takahama
    Pages 1-17

  3. Mechanisms of Thymus Medulla Development and Function

    • Graham Anderson, Song Baik, Jennifer E. Cowan, Amanda M. Holland, Nicholas I. McCarthy, Kyoko Nakamura et al.
    Pages 19-47

  4. Self-Peptides in TCR Repertoire Selection and Peripheral T Cell Function

    • Wan-Lin Lo, Paul M. Allen
    Pages 49-67

  5. Central Tolerance Induction

    • Maria L. Mouchess, Mark Anderson
    Pages 69-86

  6. Trafficking to the Thymus

    • Shirley L. Zhang, Avinash Bhandoola
    Pages 87-111

  7. The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes

    • Hirokazu Tanaka, Ichiro Taniuchi
    Pages 113-129

  8. Back Matter

    Pages 131-132
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Keywords

About this book

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Editors and Affiliations

  • Department of Developmental Immunology, Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany

    Thomas Boehm

  • Institute for Genome Research, Division of Experimental Immunology, University of Tokushima, Tokushima, Japan

    Yousuke Takahama

Bibliographic Information

  • Book Title: Thymic Development and Selection of T Lymphocytes

  • Editors: Thomas Boehm, Yousuke Takahama

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-40252-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2014

  • Hardcover ISBN: 978-3-642-40251-7Published: 19 November 2013

  • Softcover ISBN: 978-3-662-51196-1Published: 23 August 2016

  • eBook ISBN: 978-3-642-40252-4Published: 06 November 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VII, 132

  • Number of Illustrations: 2 b/w illustrations, 9 illustrations in colour

  • Topics: Immunology, Human Physiology, Cytogenetics

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