Overview
- Written by leading experts in the field of pulmonary hypertension
- Broadens your understanding of current, evidence-based pharmacological treatments of various forms of pulmonary hypertension
- Comprehensive review of most recent developments in this field including new signaling pathways
- Includes supplementary material: sn.pub/extras
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 218)
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Table of contents (22 chapters)
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Front Matter
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Pulmonary Hypertension: Conceptual Bases of the Disease
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Front Matter
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Pulmonary Hypertension: Established Therapies
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Front Matter
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Pulmonary Hypertension: Novel Pathways and Emerging Therapies
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Front Matter
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Keywords
About this book
This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.
Editors and Affiliations
Bibliographic Information
Book Title: Pharmacotherapy of Pulmonary Hypertension
Editors: Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-642-38664-0
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2013
Hardcover ISBN: 978-3-642-38663-3Published: 16 October 2013
Softcover ISBN: 978-3-662-52157-1Published: 23 August 2016
eBook ISBN: 978-3-642-38664-0Published: 04 October 2013
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: IX, 576
Number of Illustrations: 10 b/w illustrations, 56 illustrations in colour
Topics: Pharmacology/Toxicology, Pharmaceutical Sciences/Technology, Internal Medicine, Pneumology/Respiratory System, Laboratory Medicine, Molecular Medicine