Skip to main content
SpringerLink
Log in
Book cover

Environmental Epigenomics in Health and Disease

Epigenetics and Complex Diseases

  • Book
  • © 2013

Overview

Editors:
  1. Randy L. Jirtle

    1. , Department of Oncology, University of Wisconsin-Madison, Madison, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Frederick L. Tyson

    1. National Institute of Environmental Hea, NIEHS, National Institutes of Health, Research Triangle Park, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Discusses the correlation between environmental influences and brain development, neurological disorders, obesity and cancer
  • Reviews epigenetic processes that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain, discussing autism, schizophrenia and even sexual dimorphism in the developing brains of males and females
  • Includes a chapter on legal and ethical implications of epigenetics?
  • Includes supplementary material: sn.pub/extras

Part of the book series: Epigenetics and Human Health (EHH)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  3. Epigenetics and Neurological Disorders

    1. Front Matter

      Pages 55-55
      Download chapter PDF

    2. Phenotypic Plasticity, Pleiotropy, and the Growth-First Theory of Imprinting

      • Jon F. Wilkins
      Pages 57-72

    3. The Imprinted Brain: How Genes Set the Balance Between Autism and Psychosis

      • Christopher Badcock
      Pages 73-96

    4. Epigenetics at the Interface of Genetics and Environmental Factors in Autism

      • Janine M. LaSalle, Roxanne O. Vallero, Michelle M. Mitchell
      Pages 97-114

    5. Epigenomic and Noncoding RNA Regulation in Addictive Processes

      • John S. Satterlee
      Pages 115-165

    6. Epigenetic Therapies in Neurological Diseases

      • Hsien-Sung Huang, Benjamin D. Philpot, Yong-hui Jiang
      Pages 167-193

  4. Epigenetics, Nutrition, Diabetes, and Obesity

    1. Front Matter

      Pages 195-195
      Download chapter PDF

    2. Nutrition, Histone Epigenetic Marks, and Disease

      • Janos Zempleni, Dandan Liu, Jing Xue
      Pages 197-217

    3. Chromatin Switching and Gene Dynamics Associated with Type 2 Diabetes

      • Ian C. Wood
      Pages 219-233

    4. Developmental Epigenetic Programming in Diabetes and Obesity

      • Caroline L. Relton, George Davey-Smith, Susan E. Ozanne
      Pages 235-253

  5. Epigenetics and Cancer

    1. Front Matter

      Pages 255-255
      Download chapter PDF

    2. Developmental Reprogramming by Environmental Estrogens: How Early Life Exposures Affect Cancer Risk in Adulthood

      • Cheryl L. Walker
      Pages 257-267

    3. Human Cancer Epigenetics

      • F. Javier Carmona, Manel Esteller
      Pages 269-293

  6. Epigenetics and the Law

    1. Front Matter

      Pages 295-295
      Download chapter PDF

    2. Legal and Ethical Implications of Epigenetics

      • Mark A. Rothstein
      Pages 297-308
Back to top

Keywords

About this book

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this two volume book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. Consequently, epigenetic research promises to markedly improve our ability to diagnosis, prevent, and treat the pathological conditions of humans; however, it also introduces unique legal and ethical issues. This volume highlights the correlation between environmental factors and complex diseases, such as autism, addiction, neurological diseases, diabetes, obesity and cancer. It concludes with a chapter on legal and ethical implications of epigenetics. ​

Editors and Affiliations

  • , Department of Oncology, University of Wisconsin-Madison, Madison, USA

    Randy L. Jirtle

  • National Institute of Environmental Hea, NIEHS, National Institutes of Health, Research Triangle Park, USA

    Frederick L. Tyson

Bibliographic Information

  • Book Title: Environmental Epigenomics in Health and Disease

  • Book Subtitle: Epigenetics and Complex Diseases

  • Editors: Randy L. Jirtle, Frederick L. Tyson

  • Series Title: Epigenetics and Human Health

  • DOI: https://doi.org/10.1007/978-3-642-36827-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2013

  • Hardcover ISBN: 978-3-642-36826-4Published: 28 May 2013

  • Softcover ISBN: 978-3-642-43595-9Published: 23 June 2015

  • eBook ISBN: 978-3-642-36827-1Published: 13 May 2013

  • Series ISSN: 2191-2262

  • Series E-ISSN: 2191-2270

  • Edition Number: 1

  • Number of Pages: XIV, 339

  • Topics: Human Genetics, Cancer Research, Neurosciences

Publish with us

Policies and ethics

Back to top

Search

Navigation