Nevogenesis

1. Front Matter

   Pages i-viii

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2. Nevogenesis: Changing Theories

   • Mark E. Burnett, Ashfaq A. Marghoob, Alon Scope

   Pages 1-23

3. Classifying Melanocytic Nevi

   • Iris Zalaudek, Caterina Longo, Cinzia Ricci, Giuseppe Albertini, Giuseppe Argenziano

   Pages 25-41

4. Evolution of Nevi

   • Harald Kittler

   Pages 43-47

5. The Dual Pathway of Nevogenesis

   • Iris Zalaudek, Alon Scope, Giuseppe Argenziano, Caterina Longo, Simonetta Piana, Caterina Carticalà et al.

   Pages 49-57

6. Confocal Microscopy: Improving Our Understanding of Nevogenesis

   • Barbara De Pace, Barbara Ferrari, Giovanni Pellacani, Barbara Predieri, Lorenzo Iughetti, Leonardo Veneziano et al.

   Pages 59-67

7. Nevi in Children and Adults: Dermoscopic Patterns and the Development of New Nevi

   • Tracey Liebman, Natalia Jaimes Lopez, Stephen W. Dusza

   Pages 69-72

8. Etiology of Congenital Melanocytic Nevi and Related Conditions

   • Miguel Reyes-Múgica, Mark Beckwith, Heather C. Etchevers

   Pages 73-97

9. Molecular Nevogenesis: An Update

   • Andrew L. Ross, Margaret I. Sanchez, James M. Grichnik

   Pages 99-110

10. Nevogenesis: A Benign Metastatic Process?: An Update

    • Andrew L. Ross, Margaret I. Sanchez, James M. Grichnik

    Pages 111-115

11. Nevus Senescence: An Update

    • Andrew L. Ross, Margaret I. Sanchez, James M. Grichnik

    Pages 117-126

12. Genes and Nevogenesis

    • Stephen W. Dusza, Mark E. Burnett

    Pages 127-135

13. Malignant Transformation of Melanocytic Nevi

    • Alexander Marzuka-Alcalá, Hensin Tsao

    Pages 137-144

14. Disappearance of Melanocytic Nevi

    • Vitaly Terushkin, Ashfaq A. Marghoob, Alon Scope, Rainer Hofmann-Wellenhof

    Pages 145-153

15. Back Matter

    Pages 155-160

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The “Abtropfung” theory that nevi develop through the migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of these theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.

• Growth and evolution of nevi
• Involution
• Melanoma
• Nevus development
• Senescence

From the reviews:

“The purpose is to provide an update on how nevi are formed, their evolution, and factors that influence their development. I haven’t read any other book that addresses this subject in this depth. The authors do a superb job. … This should be required reading for all dermatology residents and dermatologists out of training.” (Patricia Wong, Doody’s Book Reviews, June, 2013)

• Skin Cancer Center, Hauppauge Dermatology Section, Memorial Sloan Kettering, Hauppauge, USA

  Ashfaq A. Marghoob

Ashfaq Marghoob, MD, graduated in 1987 from the School of Medicine, State University of New York at Stony Brook, where he later performed his Residency in Dermatology. He was appointed Clinical Assistant Professor in the Department of Dermatology at Stony Brook in 1995 and Associate Professor of Dermatology in 2005. Dr. Marghoob currently works at the Memorial Hospital for Cancer and Allied Diseases and is an Associate Member of Memorial Sloan-Kettering Cancer Center. He has been the recipient of various honors and awards, including a Physician’s Recognition Award from the American Medical Association, and is included in The Best Doctors in America. Dr. Marghoob has been the lead author or co-author of more than 180 articles in peer-reviewed journals and many book chapters. He is the co-author of the Handbook of Dermoscopy (Taylor & Francis 2006) and co-editor of an Atlas of Dermoscopy (Taylor & Francis 2005).

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