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Prevention of Bone Metastases

  • Book
  • © 2012

Overview

Editors:
  1. Markus Joerger

    1. , Dept. of Medical Oncology, Kantonsspital St. Gallen, St. Gallen, Switzerland

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  2. Michael Gnant

    1. Chirurgische Klinik, Abt. Allgemeine Chirurgie, Universitätsklinikum Wien, Wien, Austria

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  • Overview of current knowledge regarding the prevention of bone metastases in a variety of cancers
  • Detailed analysis of the efficacy of bisphosphonates, including in combination with cytostatics
  • Written by acknowledged experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 192)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-ix
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  2. Preclinical Models that Illuminate the Bone Metastasis Cascade

    • Geertje van der Horst, Gabri van der Pluijm
    Pages 1-31

  3. The Role of Bone Microenvironment, Vitamin D and Calcium

    • Daniele Santini, Francesco Pantano, Bruno Vincenzi, Giuseppe Tonini, Francesco Bertoldo
    Pages 33-64

  4. Bisphosphonates: Prevention of Bone Metastases in Breast Cancer

    • Michael Gnant, Peter Dubsky, Peyman Hadji
    Pages 65-91

  5. Bisphosphonates: Prevention of Bone Metastases in Lung Cancer

    • Lynn Decoster, Filippo de Marinis, Kostas Syrigos, Vera Hirsh, Kristiaan Nackaerts
    Pages 93-108

  6. Bisphosphonates: Prevention of Bone Metastases in Prostate Cancer

    • Fred Saad, Jean-Baptiste Lattouf
    Pages 109-126

  7. Targeting Bone in Myeloma

    • G. J. Morgan, Ping Wu
    Pages 127-143

  8. Combinations of Bisphosphonates and Classical Anticancer Drugs: A Preclinical Perspective

    • Maria Michailidou, Ingunn Holen
    Pages 145-169

  9. Perspectives in the Elderly Patient: Benefits and Limits of Bisphosphonates and Denosumab

    • Daniele Santini, Maria Elisabetta Fratto, Matti Aapro
    Pages 171-185

  10. Denosumab: First Data and Ongoing Studies on the Prevention of Bone Metastases

    • Roger von Moos, Tomas Skacel
    Pages 187-196

  11. Diagnostic and Prognostic Use of Bone Turnover Markers

    • Markus Joerger, Jens Huober
    Pages 197-223

  12. Osteolytic and Osteoblastic Bone Metastases: Two Extremes of the Same Spectrum?

    • Angelica Ortiz, Sue-Hwa Lin
    Pages 225-233
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Keywords

About this book

Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. One important focus of the book is the efficacy of bisphosphonates in preventing bone metastases in patients with breast, lung, and prostate cancer and disease progression in cases of multiple myeloma. The combined use of bisphosphonates and cytostatics is also discussed, with a report on first clinical data. Further topics addressed include the significance of the bone microenvironment, special issues in the elderly patient, the use of bone turnover markers, and initial findings obtained with denosumab.

Editors and Affiliations

  • , Dept. of Medical Oncology, Kantonsspital St. Gallen, St. Gallen, Switzerland

    Markus Joerger

  • Chirurgische Klinik, Abt. Allgemeine Chirurgie, Universitätsklinikum Wien, Wien, Austria

    Michael Gnant

Bibliographic Information

  • Book Title: Prevention of Bone Metastases

  • Editors: Markus Joerger, Michael Gnant

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-21892-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2012

  • Hardcover ISBN: 978-3-642-21891-0Published: 05 January 2012

  • Softcover ISBN: 978-3-642-44614-6Published: 22 February 2014

  • eBook ISBN: 978-3-642-21892-7Published: 03 February 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: X, 234

  • Topics: Oncology, Surgical Oncology

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