Brain, Behavior and Epigenetics

1. Front Matter

   Pages i-xvi

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2. Posttranslational Histone Modifications and the Neurobiology of Psychosis

   • Schahram Akbarian, Iris Cheung, Caroline Connor, Mira Jakovcevski, Yan Jiang

   Pages 1-21

3. Epigenetic Regulation of GABAergic Targets in Psychiatry

   • Dennis R. Grayson, Marija Kundakovic, Ying Chen, Erbo Dong, Alessandro Guidotti

   Pages 23-40

4. Possible Roles of DNA Methylation in Bipolar Disorder

   • Tadafumi Kato

   Pages 41-47

5. The Epigenetics of Depression and Suicide

   • Benoit Labonté, Gustavo Turecki

   Pages 49-70

6. Epidemiology Research and Epigenetics: Translational Epidemiology of Schizophrenia

   • Mary Perrin, Karine Kleinhaus, Mark Opler, Julie Messinger, Dolores Malaspina

   Pages 71-96

7. Environmental Studies as a Tool for Detecting Epigenetic Mechanisms in Schizophrenia

   • Wim Veling, L. H. Lumey, Bas Heijmans, Ezra Susser

   Pages 97-118

8. Imprinting, Inactivation and the Behavioural Genetics of the X Chromosome

   • Ian W. Craig

   Pages 119-141

9. The Strategies of the Genes: Genomic Conflicts, Attachment Theory, and Development of the Social Brain

   • Bernard J. Crespi

   Pages 143-167

10. Genomic Imprinting Effects on Brain and Behavior: Future Directions

    • Anthony R. Isles, Lawrence S. Wilkinson

    Pages 169-184

11. Epigenetic Influence of the Social Environment

    • Frances A. Champagne, James P. Curley

    Pages 185-208

12. Toward an Understanding of the Dynamic Interdependence of Genes and Environment in the Regulation of Phenotype

    • Ian C. G. Weaver

    Pages 209-243

13. Histone Deacetylase Inhibitors: A Novel Therapeutic Approach for Cognitive Disorders

    • Viviane Labrie

    Pages 245-266

14. Epigenetic Mechanisms of Memory Consolidation

    • Marcel A. Estevez, Ted Abel

    Pages 267-285

15. Epigenetic Mechanisms in Memory Formation

    • Johannes M. H. M. Reul, Andrew Collins, María Gutièrrez-Mecinas

    Pages 287-300

16. Back Matter

    Pages 301-317

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Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

• GABA
• acetylation
• attachment theory
• bipolar disorder
• chromatin remodelling
• cognitive disorder
• depression
• genomic imprinting
• histone modifications
• memory formation
• phosphorylation
• schizophrenia
• suicide
• transgenerational inheritance
• twin studies
• x-inactivation

• , The Krembil Family Epigenetics Laborator, Centre for Addiction and Mental Health, Toronto, Canada

  Arturas Petronis

• , Institute of Psychiatry, King's College London, London, United Kingdom

  Jonathan Mill

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